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Table 1 Genes up-regulated in A. pleuropneumoniae under iron limitation

From: Comparative profiling of the transcriptional response to iron restriction in six serotypes of Actinobacillus pleuropneumoniae with different virulence potential

Locus tag* Gene Gene function COGs** Ratio
(log2)
APL_2002 - hypothetical protein P 0.75
APL_1974 argD1 diaminobutyrate-2-oxoglutarate aminotransferase E 0.20
APL_1957+ - Lipoprotein_5 domain containing protein S 3.36
APL_1956+ - Putative N-methylhydantoinase B/acetone carboxylase, alpha subunit S 2.74
APL_1955+ hpuB # Probable hemoglobin-haptoglobin-binding protein 2 precursor P 1.63
APL_1954+ hpuB # Hemoglobin-haptoglobin utilization protein B precusor P 1.70
APL_1953+ hpuB # Hemoglobin-haptoglobin-binding protein A precursor P 1.03
APL_1849+ lldD L-lactate dehydrogenase [cytochrome] C 2.04
APL_1806 - hypothetical protein S 0.98
APL_1571+ tonB1 Periplasmic protein M 1.46
APL_1570+ exbB1 Biopolymer transport protein U 2.35
APL_1569+ exbD1 Biopolymer transport protein U 1.77
APL_1568+ tbpB1 Transferrin-binding protein 2 precursor P 0.92
APL_1567+ tbpA1 Transferrin-binding protein 1; tonB dependent receptor P 1.24
APL_1566 - Hypothetical protein S 1.40
APL_1565 - Putative gluconolactonase (Glucose secondary pathway) G 1.42
APL_1564+ xylB1 Sugar (Pentulose and hexulose) kinase G 1.20
APL_1523+ chuW Probable oxygen-independent coproporphyrinogen III oxidase H 0.62
APL_1522 - Predicted nucleoside-diphosphate-sugarepimerase MG 0.88
APL_1350+ tehB Tellurite resistance protein P 0.73
APL_1299+ hemR Iron-regulated OM protein; tonB dependent receptor P 1.19
APL_1271+ ndh NADH dehydrogenase (part of oxidative phosphorylation pathway) C 0.37
APL_1265 copA Copper-transporting P-type ATPase P 1.46
APL_1264 - Cation transport ATPase P 1.81
APL_1263 - Predicted metal-binding protein R 1.60
APL_1048+ hugZ Putative heme utilization protein P 2.41
APL_1047+ hgbA Probable haemoglobin-and-haptoglobin binding protein 4 P 1.81
APL_1046 lysE Lysine exporter protein E 1.84
APL_1045+ rarD Predicted permease R 0.66
APL_0762 - SAM-dependent methyltransferase Q 0.29
APL_0716 - Iron(III) ABC transporter, permease protein P 0.40
APL_0715 - Iron(III) transport system permease protein P 0.43
APL_0714+ FatB ABC-type enterochelin transport system, periplasmic component P 0.36
APL_0669+ ywbN Putative iron dependent peroxidase P 0.75
APL_0668+ - Predicted periplasmic lipoprotein involved in iron transport P 0.66
APL_0656+ hlyX Fumarate/nitrate reduction transcriptional regulator T 0.52
APL_0585 - AcrR protein, putative HTH-type transcriptional regulator K 0.29
APL_0565 cirA Hypothetical ABC transporter ATP-binding protein P 0.67
APL_0271+ yfeB Iron (chelated) transporter, ATP-binding protein P 0.76
APL_0149 nfuA Fe/S biogenesis protein O 0.62
APL_0129 rnhB RNase HII; binds manganese; endonuclease which specifically degrades the RNA of RNA-DNA hybrids (DNA synthesis pathway) L 0.50
APL_0128+ yfeC Putative iron transport system membrane protein P 0.45
APL_0127+ yfeD Iron (chelated) transport system membrane protein P 0.42
APL_0076+ tonB2 Protein tonB M 0.41
(APL_0073 ydhD Conserved monothiol glutaredoxin-like protein O 0.47
  1. * Organized according to Locus tag numbers of A. pleuropneumoniae serotype 5 in GenBank.
  2. ** Clusters of Orthologous Groups.
  3. + Genes in common with A. pleuropneumoniae serotype 1 [26].
  4. # Genes significantly differentially expressed among serotypes.