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Table 1 Genes up-regulated in A. pleuropneumoniae under iron limitation

From: Comparative profiling of the transcriptional response to iron restriction in six serotypes of Actinobacillus pleuropneumoniae with different virulence potential

Locus tag*

Gene

Gene function

COGs**

Ratio

(log2)

APL_2002

-

hypothetical protein

P

0.75

APL_1974

argD1

diaminobutyrate-2-oxoglutarate aminotransferase

E

0.20

APL_1957+

-

Lipoprotein_5 domain containing protein

S

3.36

APL_1956+

-

Putative N-methylhydantoinase B/acetone carboxylase, alpha subunit

S

2.74

APL_1955+

hpuB #

Probable hemoglobin-haptoglobin-binding protein 2 precursor

P

1.63

APL_1954+

hpuB #

Hemoglobin-haptoglobin utilization protein B precusor

P

1.70

APL_1953+

hpuB #

Hemoglobin-haptoglobin-binding protein A precursor

P

1.03

APL_1849+

lldD

L-lactate dehydrogenase [cytochrome]

C

2.04

APL_1806

-

hypothetical protein

S

0.98

APL_1571+

tonB1

Periplasmic protein

M

1.46

APL_1570+

exbB1

Biopolymer transport protein

U

2.35

APL_1569+

exbD1

Biopolymer transport protein

U

1.77

APL_1568+

tbpB1

Transferrin-binding protein 2 precursor

P

0.92

APL_1567+

tbpA1

Transferrin-binding protein 1; tonB dependent receptor

P

1.24

APL_1566

-

Hypothetical protein

S

1.40

APL_1565

-

Putative gluconolactonase (Glucose secondary pathway)

G

1.42

APL_1564+

xylB1

Sugar (Pentulose and hexulose) kinase

G

1.20

APL_1523+

chuW

Probable oxygen-independent coproporphyrinogen III oxidase

H

0.62

APL_1522

-

Predicted nucleoside-diphosphate-sugarepimerase

MG

0.88

APL_1350+

tehB

Tellurite resistance protein

P

0.73

APL_1299+

hemR

Iron-regulated OM protein; tonB dependent receptor

P

1.19

APL_1271+

ndh

NADH dehydrogenase (part of oxidative phosphorylation pathway)

C

0.37

APL_1265

copA

Copper-transporting P-type ATPase

P

1.46

APL_1264

-

Cation transport ATPase

P

1.81

APL_1263

-

Predicted metal-binding protein

R

1.60

APL_1048+

hugZ

Putative heme utilization protein

P

2.41

APL_1047+

hgbA

Probable haemoglobin-and-haptoglobin binding protein 4

P

1.81

APL_1046

lysE

Lysine exporter protein

E

1.84

APL_1045+

rarD

Predicted permease

R

0.66

APL_0762

-

SAM-dependent methyltransferase

Q

0.29

APL_0716

-

Iron(III) ABC transporter, permease protein

P

0.40

APL_0715

-

Iron(III) transport system permease protein

P

0.43

APL_0714+

FatB

ABC-type enterochelin transport system, periplasmic component

P

0.36

APL_0669+

ywbN

Putative iron dependent peroxidase

P

0.75

APL_0668+

-

Predicted periplasmic lipoprotein involved in iron transport

P

0.66

APL_0656+

hlyX

Fumarate/nitrate reduction transcriptional regulator

T

0.52

APL_0585

-

AcrR protein, putative HTH-type transcriptional regulator

K

0.29

APL_0565

cirA

Hypothetical ABC transporter ATP-binding protein

P

0.67

APL_0271+

yfeB

Iron (chelated) transporter, ATP-binding protein

P

0.76

APL_0149

nfuA

Fe/S biogenesis protein

O

0.62

APL_0129

rnhB

RNase HII; binds manganese; endonuclease which specifically degrades the RNA of RNA-DNA hybrids (DNA synthesis pathway)

L

0.50

APL_0128+

yfeC

Putative iron transport system membrane protein

P

0.45

APL_0127+

yfeD

Iron (chelated) transport system membrane protein

P

0.42

APL_0076+

tonB2

Protein tonB

M

0.41

(APL_0073

ydhD

Conserved monothiol glutaredoxin-like protein

O

0.47

  1. * Organized according to Locus tag numbers of A. pleuropneumoniae serotype 5 in GenBank.
  2. ** Clusters of Orthologous Groups.
  3. + Genes in common with A. pleuropneumoniae serotype 1 [26].
  4. # Genes significantly differentially expressed among serotypes.