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Table 2 Genes down-regulated in A. pleuropneumoniae under iron limitation

From: Comparative profiling of the transcriptional response to iron restriction in six serotypes of Actinobacillus pleuropneumoniae with different virulence potential

Locus tag Gene Gene function COG** Ratio
(log2)
APL_1757+ fumC fumarate hydratase C -0.83
APL_1675 dms B anaerobic dimethyl sulfoxide reductase chain B C -2.00
APL_1674+ dmsA Anaerobic dimethyl sulfoxide reductase chain A precursor C -2.07
APL_1572 - Predicted membrane protein S -0.67
APL_1546 hcp hydroxylamine reductase, catalyzes the reduction of hydroxylamine to ammonia and water (Fe-S cluster containing protein) C -1.28
APL_1529+ frdA Fumarate reductase flavoprotein subunit C -0.90
APL_1528+ frdB Fumarate reductase iron-sulfur subunit C -0.90
APL_1527+ frdC Fumarate reductase subunit C C -1.39
APL_1526 frdD Fumarate reductase subunit D C -1.37
APL_1496   Predicted esterase R -0.24
APL_1432 - Putative NAD(P)H oxidoreductase R -0.66
APL_1431+ napF Ferredoxin-type protein C -1.23
APL_1430 napD putative periplasmic nitrate reductase protein P -1.66
APL_1429 napA Periplasmic nitrate reductase C -1.14
APL_1428 napG Quinol dehydrogenase periplasmic component C -1.39
APL_1427 napH Quinol dehydrogenase membrane component C -1.14
APL_1426 napB Nitrate reductase cytochrome c-type subunit C -1.60
APL_1422 napC Nitrate/TMAO reductase C -1.42
APL_1379 mauG # Cytochrome c peroxidase P -1.95
APL_1367+ ccmF Cytochrome c-type biogenesis protein O -0.54
APL_1337 hypG Hydrogenase maturation factor O -0.68
APL_1336 hybE Hydrogenase 2-specific chaperone S -1.00
APL_1335 hyaD Ni, Fe-hydrogenase maturation factor C -0.99
APL_1334 hyaB Ni, Fe-hydrogenase I large subunit C -1.06
APL_1333 hybB Putative cytochrome b subunit of the hydrogenase 2 C -1.17
APL_1332 hybA2 Fe-S-cluster-containing hydrogenase components 1 C -1.95
APL_1331+ hyaA # Ni, Fe-hydrogenase I small subunit C -2,51
APL_1328 hybD # Hydrogenase maturation factor O -1.90
APL_1327 hypB # Hydrogenase nickel incorporation protein OK -2.1
APL_1316+ dcuB2 Anaerobic C4-dicarboxylate membrane transporter R -0.78
APL_1253 - Di- and tricarboxylate transporter P -0.83
APL_1216 luxS S-ribosylhomocysteine lyase T -0.39
APL_1213 - Predicted phosphatase/phosphohexomutase R -1.21
APL_1237 - Possible integral membrane sulfate transporter P -0.64
APL_1162 - Predicted iron-dependent peroxidase P -0.41
APL_1156 citT Di-and tricarboxylate transporter P -1.20
APL_1129 cytB562 Soluble cytochrome b562 C -0.48
APL_1124+ pfkA 6-phosphofructokinase G -0.37
APL_1086+ ompW OM protein ompW precursor M -1.53
APL_1036+ pflB Formate acetyltransferase C -0.38
APL_1011+ adh2 Alcohol dehydrogenase, class IV/NAD-dependent aldehyde dehydrogenases C -1.24
APL_0966 - Putative transport protein R -0.71
APL_0895 fdnI Formate dehydrogenase, gamma subunit C -1.15
APL_0894+ fdxH Formate dehydrogenase, iron-sulfur subunit C -1.17
APL_0893+ fdxG Formate dehydrogenase, nitrate-inducible, major subunit C -1.01
APL_0892 fdxG Formate dehydrogenase, nitrate-inducible, major subunit C -1.18
APL_0857 sdaA # L-serine dehydratase (gluconeogenesis) E -1.00
APL_0856 sdaC # serine transporter E -1.58
APL_0780 lrgA2 # Putative effector of murein hydrolase LrgA R -1.11
APL_0779 - Putative effector of murein hydrolase M -0.90
APL_0723 tgt Queuine tRNA-ribosyltransferase J -0.15
APL_0689+ torY Cytochrome c-type protein C -2.30
APL_0688+ torZ Trimethylamine-N-oxide reductase precursor C -1.61
APL_0607+ nfnB Putative NAD(P)H nitroreductase C -0.54
APL_0446+ ykgE Putative dehydrogenase subunit, Fe-S oxidoreductase C -2.63
APL_0445+ ykgF Iron-sulfur electron transport protein C -1.79
APL_0444+ engA Putative GTP binding protein S -1.10
APL_0416 - N-acetyl-D-glucosamine kinase KG -0.36
APL_0155+ nqrF Na+-translocating NADH-ubiquinone oxidoreductase subunit F C -0.37
APL_0154+ nqrE Na+-transporting NADH-ubiquinone oxidoreductase subunit E C -0.35
APL_0153+ nqrD Na+-translocating NADH-ubiquinone oxidoreductase subunit D C -0.47
APL_0152+ nqrC Na+-translocating NADH-ubiquinone oxidoreductase subunit C C -0.33
APL_0151+ nqrB Na+-translocating NADH-ubiquinone oxidoreductase subunit B C -0.40
APL_0150+ nqrA Na+-translocating NADH-ubiquinone oxidoreductase subunit A C -0.46
APL_0103 nrfD # Nitrate reductase, transmembrane protein P -1.51
APL_0101+ nrfB # Cytochrome c nitrite reductase pentaheme subunit C -2.17
APL_0100+ nrfA # Nitrate reductase, cytochrome c552, catalyzes the formate-dependent reduction of nitrite to ammonia; P -2.34
  1. * Organized according to Locus tag numbers of A. pleuropneumoniae serotype 5 in GenBank.
  2. ** Clusters of Orthologous Groups.
  3. + Genes in common with A. pleuropneumoniae serotype 1 [26].
  4. # Genes significantly differentially expressed among serotypes.