Figure 2

Novel domain combinations in P. infestans ePKs. Indicated are six proteins that contain accessory domains not described previously for ePKs, drawn approximately to scale. The novel domains are RhoGAP, a domain found on GTPase activating proteins; the WW protein interaction domain, which was found on a dual-kinase protein; the Arb2 domain which associates with chromatin and may influence histone methylation and siRNA formation; the N and C-terminal alpha fold domains of cyclins, cyc_N and cyc_C, which may be cell cycle control or protein interaction domains; the RyR ryanodine receptor domain, which are found on some Ca²⁺ channels and other proteins but have unknown functions; and the PAS signal sensor domain. The latter is located just upstream of PAC, which is a structural domain that is believed to contribute to the activity of the PAS fold. PITG_12903 also contains a predicted phosphatidylinositol-binding PH (Pleckstrin Homology) domain, which is commonly found on ePKs, as is the zinc and phosphatidylinositol 3-phosphate-binding FYVE domain shown on PITG_01365.