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Table 2 Evaluation of asMIPs using splicing controls and qPCR data

From: A molecular inversion probe assay for detecting alternative splicing

Statistic

R-Array

R-Seq

M-Array

M-Seq

AUC-controls1

0.90

0.96

0.89

0.96

AUC-qPCR2

0.65

0.65

0.65

0.76

CorrqPCR-controls3 (ρ)

0.84

0.86

0.63

0.82

CorrqPCR-total2 (ρ)

0.44

0.64

0.29

0.59

  1. The table includes results from both the R- and M-score analyses (R- and M-), as well as data from asMIPs quantified with either arrays (Array) or sequencing (Seq). AUC and Pearson correlation (Corr, ρ) values are reported.
  2. 1 asMIP data was compared to tissue specific, splicing controls from the literature: 58 tissue specific, alternatively spliced junctions [10, 20] and 99 predicted constitutive junctions [21, 34].
  3. 2 asMIP data was compared to the complete set of qPCR data, 235 tissue specific splice events were analyzed.
  4. 3 asMIP data from the set of splicing controls was compared to qPCR data from the same set of controls [10, 20, 21, 34], 34 tissue specific splice events were analyzed.