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Table 3 Summary of all QTL pairs detected using pair-wise scans in the F2 mice.

From: Genetic and genomic analysis of hyperlipidemia, obesity and diabetes using (C57BL/6J × TALLYHO/JngJ) F2 mice

 

QTL 1

  

QTL 2

  

LOD

  

%

Trait

Chr

Best location (cM)

Closest marker to peak LOD

Chr

Best location (cM)

Closest marker to peak LOD

Full

Add

Int

 

Glu 12 wk

15

53.7

D15Mit2

19

27

D19Mit30

10.4

3.6

6.8

8.5

 

5

36

D5Mit80

7

28.7

D7Mit231

9.3

2.9

6.4

6.5

 

12

53

D12Mit233

19

28

D19Mit30

9.3

2.8

6.5

5.8

Tg 16 wk

3

21.6

D3Mit304

13

38

D13Mit26

12.3

2.1

10.2

4.8

Tg 20 wk

7

79.7

D7Mit109

14

59.5

D14Mit102

11.7

1.3

10.4

4.8

 

10

24

D10Mit130

17

75

D17Mit123

10.8

2.8

8.1

5.0

 

5

99

D5Mit101

16

51.3

D16Mit152

11.1

0.9

10.2

3.1

Chol 8 wk

5

33

D5Mit80

17

30

D17Mit54

12.9

2.1

10.8

4.8

 

5

107

D5Mit101

14

57.5

D14Mit107

9.3

1.9

7.4

4.0

Chol 24 wk

1

68.7

D1Mit26

10

50

D10Mit11

13.4

5.8

7.6

7.5

 

15

45.7

D5Mit2

16

57.3

D16Mit152

10.5

2.0

8.6

4.2

 

4

14.3

D4Mit97

5

98

D5Mit101

13.6

1.8

11.8

3.7

IG FPW

7

82.7

D7Mit109

8

52

D8Mit242

9.9

3.0

6.9

3.7

Sum FPW

7

71.7

D7Mit109

17

76

D17Mit123

9.8

2.7

7.1

3.9

  1. Chr, chromosome; Full, the Lod score for the full model (including additive effects and interaction); Add, the Lod score for two locus additive effects; Int, the Lod score for the interaction (Full - Add); %, total variance explained by R-square; Glu, glucose; Tg, trighlyceride; Chol, cholesterol; IG FPW, inguinal fat pad weight; Sum FPW, sum of the 5 regional fat pad weights; wk, week.