Combining modularity, conservation, and interactions of proteins significantly increases precision and coverage of protein function prediction

Table 1 Characteristics of the generated species-specific PPI networks.

species	#proteins	#PPIs	GO terms/protein	median PPI/protein
R. norvegicus (rno)	973	1221	8	1
M. musculus (mmu)	3892	4670	4	1
H. sapiens (hsa)	13494	43637	2	2
D. melanogaster (dme)	10646	38723	3	3
C. elegans (cel)	3499	5858	1	1
S. cerevisiae (sce)	6578	67059	4	7

PPI networks for each species are created by integrating PPI data from DIP, BIND, IntAct, BioGrid, MIPS-MPPI, MINT and HPRD. Proteins within the networks are additionally associated with sequences, protein domains and GO annotations. For each species the number of proteins and protein interactions as well as the median number of GO terms per protein is specified.

ISSN: 1471-2164