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Table 3 Comparison of α levels when restricting the definition of a haplotype

From: Accounting for multiple comparisons in a genome-wide association study (GWAS)

Method Parameters Significance Threshold Corresponding α level
Gabriel D'U > 0.98 2.72 × 10-7 0.151
  D'L > 0.70   
  D'U > 0.98 2.11 × 10-7 0.12
  D'L > 0.85   
4-Gamete Cutoff = 1% 3.06 × 10-7 0.166
  Cutoff = 0.5% 2.50 × 10-7 0.139
Solid spine D' = 0.80 3.71 × 10-7 0.195
  D' = 0.95 2.79 × 10-7 0.155
  1. Significance thresholds with corresponding α levels are given for each haplotype calling method with the standard parameters and a set of more restricted parameters. D'U and D'L represent the, upper and lower confidence limits of D', respectively.