Figure 4

Regulons involved in the oxidative stress response and in zinc and manganese regulation of C. pseudotuberculosis FRC41. (A), The OxyR regulon controlling the oxidative stress response. (B), The MntR operon controlling the uptake of manganese. (C), The Zur regulon controlling zinc metabolism. The assignment of the transcription regulators into the regulatory protein families of C. pseudotuberculosis FRC41 is indicated. The regulatory interactions were deduced from a genome-scale network transfer approach [114] and the combined use of a hidden Markov model and a position weight matrix [74]. Predicted DNA-binding sites are shown as black boxes and indicated by DNA sequence. The regulated target genes are shown as arrows and coloured as follows: grey, regulatory gene; red, gene contributing to the oxidative stress response; dark blue, gene involved in maganese uptake; light blue, gene involved in zinc metabolism.