Table 1 Functional classification of domains associated with FYVE and PX
Functional categories | FYVE-associated domains | PX-associated domains |
|---|---|---|
Signal transduction mechanisms | PH, RhoGEF, PIP5K, RUN, DEP, PDEase_I, Arm, Arrestin_N, SH2, Arrestin_C, Miro, NB-ARC, Ras, TIR, zf-TRAF | PH, RhoGEF, RUN, Ras, RGS, PB1, C2, PI3K_C2, RA, FHA, PDZ, Pkinase_C, RhoGAP, IQ, CH |
Intracellular trafficking, secretion, and vesicular transport | VHS, EMP24_GP25L, Rab5-bind, Zf-RanBP, Rabaptin | Vps5, Nexin_C, Sorting_nexin, MIT, PI3Ka, SNARE, Kinesin, VPS9, BAR, SRPRB, TBC |
Chaperone | Cpn60_TCP1 | AAA |
Cell cycle control, cell division, chromosome partitioning | RCC1, DZC, Septin | PI3K_rbd |
Cytoskeleton | PH, WH2 | PH, WH2, SH3_1, SH3_2, SH3_3, FERM_M, CAP_GLY, CH |
Transcription | Zn_clus | Â |
Translation | Ribosomal_L1 | L15, Ribosomal_L15, tRNA_anti |
Defence mechanisms | Â | p47_phox_C, GBP |
Inorganic ion transport | Â | Sulfate_transp |
Protein-protein interaction | WD40, UIM, Ank, zf-C3HC4, BTB, TPR_1, LRR_1, LRR_3, PAN_1, WW, zf_AN1 | WD40, UIM, Ank, LRR_1 |
Catalytic | Pkinase, Glyco_transf_28, PI3_PI4_kinase, Abhydrolase_3, Glyco_tran_28_C, Lipase_GDSL, Orn_Arg_deC_N, Pkinase_Tyr, Myotub-related | Pkinase, PI3_PI4_kinase, Pkinase_Tyr, PLDc, 4HBT, ADH_N, ADH_zinc_N, AhpC-TSA, rve, glutaminase, Glyco_hydro_18, Myotub-related, Proteasome, Radical_SAM, RmlD_sub_bind, RNA_pol_Rpb4 |
Metabolism | Â | FAD_binding_2, FAD_binding_4, Succ_DH_flav_C |
Replication, recombination & repair | Â | Retrotrans_gag |
General function prediction only | GRAM, LysM | cNMP_binding, DDE, FLYWCH, Methyltransf_4, Peptidase_A17, Zf-B_box |
Function unclear | Beach, DUF500, MORN, MtN3_slv, Cupin_2, NIF, TPR_2, zf-DHHC | TPR_2, PXA, DUF399, CNH, DUF1388, DUF1879, Kelch_1, Kelch_2, LIM, M, Met_10, Pinin_SDK_memA, SAM_1, STAS, UPF0047 |