Figure 4

Sequence composition and distribution of the novel Sirevirus RMs. (A) Alignment of the Sirevirus palindromic RM boxes (refer to Table 3 for the intervening bases of each RM), (B) and their organization (pink boxes) in four elements at the 5' side of the ENV gene (only HOPIE and Inga), and upstream of the TATA box (blue circle) in the 3'LTR. All or a section of the RM clusters define the borders of CpG islands (orange bar) (all elements are shown in Figure S4 in Additional file 2)