Table 1 Liver and body weights, Ki67 labeling indices and plasma clinical biochemistry
From: An integrated functional genomic study of acute phenobarbital exposure in the rat
| Â | Â | Dose PB | |||
|---|---|---|---|---|---|
| Â | Â | Control | 50 ppm | 500 ppm | 1000 ppm |
Day 1 | Relative liver weight (%) | 4.57 ± 0.17 | 4.67 ± 0.12 | 4.89 ± 0.09** | 4.58 ± 0.15 |
|  | Body weight (g) | 205.8 ± 3.6 | 207.0 ± 6.9 | 210.2 ± 9.0 | 207.2 ± 8.8 |
|  | Ki67 labeling index (%) | 6.77 ± 2.54 | 8.63 ± 2.56 | 7.94 ± 2.41 | 9.87 ± 2.88 |
|  | Total Protein (g/l) | 62.9 ± 1.1 | 62.7 ± 1.7 | 63.9 ± 1.8 | 62.8 ± 2.0 |
|  | Cholesterol (mmol/l) | 1.39 ± 0.06 | 1.35 ± 0.08 | 1.41 ± 0.11 | 1.39 ± 0.12 |
|  | Triglycerides (mmol/l) | 1.27 ± 0.26 | 1.20 ± 0.07 | 1.56 ± 0.17 | 1.40 ± 0.44 |
|  | Alkaline Phosphatase (IU/l) | 1120 ± 27 | 1071 ± 35 | 1117 ± 103 | 1048 ± 106 |
|  | Glutamate Dehydrogenase (U/l) | 5.56 ± 0.48 | 6.62 ± 1.29 | 6.62 ± 1.55 | 5.64 ± 0.61 |
Day 3 | Relative liver weight | 4.73 ± 0.25 | 4.97 ± 0.21 | 5.17 ± 0.27* | 5.63 ± 0.21** |
|  | Body weight (g) | 216.4 ± 10.4 | 214.8 ± 11.6 | 217.0 ± 7.8 | 209.0 ± 12.2 |
|  | Ki67 labeling index (%) | 6.92 ± 0.73 | 6.14 ± 0.74 | 9.65 ± 0.58** | 11.13 ± 1.73** |
|  | Total Protein (g/l) | 63.7 ± 3.7 | 62.9 ± 0.6 | 63.6 ± 3.6 | 64.8 ± 3.6 |
|  | Cholesterol (mmol/l) | 1.38 ± 0.09 | 1.52 ± 0.15 | 1.72 ± 0.14* | 1.86 ± 0.34** |
|  | Triglycerides (mmol/l) | 1.27 ± 0.17 | 1.29 ± 0.35 | 1.36 ± 0.25 | 1.33 ± 0.42 |
|  | Alkaline Phosphatase (IU/l) | 1125 ± 112 | 1081 ± 38 | 942 ± 142 | 864 ± 133** |
|  | Glutamate Dehydrogenase (U/l) | 6.28 ± 0.53 | 5.43 ± 0.36 | 5.54 ± 0.94 | 5.82 ± 0.79 |
Day 7 | Relative liver weight | 4.31 ± 0.13 | 4.66 ± 0.12** | 5.37 ± 0.17** | 5.7 ± 0.14** |
|  | Body weight (g) | 225.6 ± 4.7 | 229.8 ± 12.1 | 228.8 ± 8.3 | 231.4 ± 6.7 |
|  | Ki67 labeling index (%) | 5.08 ± 0.33 | 4.33 ± 1.12 | 4.63 ± 1.12 | 4.35 ± 1.21 |
|  | Total Protein (g/l) | 61.0 ± 0.8 | 61.5 ± 1.1 | 64.3 ± 1.7** | 66.3 ± 1.7** |
|  | Cholesterol (mmol/l) | 1.44 ± 0.10 | 1.41 ± 0.12 | 1.74 ± 0.07** | 1.92 ± 0.08** |
|  | Triglycerides (mmol/l) | 1.04 ± 0.28 | 1.26 ± 0.11 | 0.90 ± 0.26 | 0.85 ± 0.07 |
|  | Alkaline Phosphatase (IU/l) | 1007 ± 60 | 986 ± 95 | 883 ± 48* | 837 ± 51** |
|  | Glutamate Dehydrogenase (U/l) | 4.70 ± 0.12 | 5.78 ± 0.43* | 6.26 ± 0.79** | 6.64 ± 0.52** |
Day 14 | Relative liver weight | 4.22 ± 0.16 | 4.43 ± 0.18 | 5.39 ± 0.23** | 5.7 ± 0.16** |
|  | Body weight (g) | 232.2 ± 7.8 | 240.6 ± 6.5 | 258.0 ± 11.4 | 266.2 ± 13.7 |
|  | Ki67 labeling index (%) | 2.03 ± 1.04 | 1.10 ± 0.26 | 1.38 ± 0.49 | 1.83 ± 0.63 |
|  | Total Protein (g/l) | 60.9 ± 0.9 | 59.8 ± 1.5 | 64.5 ± 1.9* | 65.3 ± 3.2** |
|  | Cholesterol (mmol/l) | 1.22 ± 0.07 | 1.14 ± 0.10 | 1.42 ± 0.13* | 1.60 ± 0.17** |
|  | Triglycerides (mmol/l) | 1.15 ± 0.11 | 1.23 ± 0.20 | 0.68 ± 0.10** | 0.53 ± 0.14** |
|  | Alkaline Phosphatase (IU/l) | 952 ± 55 | 889 ± 149 | 821 ± 39 | 765 ± 14** |
|  | Glutamate Dehydrogenase (U/l) | 5.76 ± 1.26 | 6.56 ± 2.37 | 5.06 ± 0.86 | 6.92 ± 0.86 |