An integrated functional genomic study of acute phenobarbital exposure in the rat

BMC Genomics

Table 3 Fold change in expression of selected genes.

	Fold change relative to time matched controls
Time point	Day 1			Day 3			Day 7			Day 14
Dose (ppm)	50	500	1000	50	500	1000	50	500	1000	50	500	1000
hexokinase D	1.10	0.67	0.23*	0.99	0.84	0.41	0.85	0.30*	0.39*	0.64	0.44*	0.40
glutamine synthetase	1.09	0.60**	0.57**	0.83	0.48**	0.39**	1.01	0.46*	0.45**	0.80*	0.44**	0.30*
glutamine cysteine ligase	1.00	1.28	1.59*	1.11	1.76**	1.80**	0.64**	0.69**	0.92	1.06	1.16	1.04
glutathione reductase	1.14	1.30*	1.57**	1.16	1.86**	1.99**	0.79	1.33**	1.74**	0.94	1.43	1.61*
malic enzyme	1.38	1.84**	1.72*	0.77	1.64*	1.87**	0.87	1.13	1.71	1.19	2.15*	1.74
aminolevulinate synthase	1.84	2.54*	3.68**	1.06	1.77*	2.29**	1.26	1.54	2.05	0.83	1.40	1.39
lipoprotein lipase	0.83*	0.95	1.19	1.13	1.69	2.32**	1.13	3.94**	7.33**	0.81	4.19**	5.16**
epoxide hydrolase	1.36*	2.19**	2.57**	1.14	2.46**	2.88**	1.15	2.38**	2.67**	1.72*	3.33**	3.33**
CYP 3A 3	1.21	1.66**	1.74**	0.97	1.71**	1.84**	1.02	1.69**	1.70**	1.04	1.58**	1.81**
Aldehyde dehydrogenase 1 A1	1.41	2.69*	4.87**	1.28	6.09*	9.82**	1.31	8.70**	14.11**	3.93	23.86**	24.59**
liver UDP-glucuronosyltransferase, PB-inducible form	1.88	3.96**	4.98**	2.77**	6.45**	6.71**	3.97**	6.18**	6.63**	3.63**	6.10**	5.89**
glutathione S-transferase Yb4 gene	0.91	1.73	2.19	1.65	6.27**	9.01**	1.45	6.19**	8.44**	1.80	6.56**	7.89**
CYP 2B2	4.23*	7.30**	7.06**	5.74**	8.75**	9.16**	5.58**	8.08**	7.01**	6.19**	8.48**	8.71**

Fold changes in expression for selected genes. * p < 0.05 compared to time matched controls, ** p < 0.01 compared to time matched controls.

ISSN: 1471-2164