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Table 4 Number of occurrences of fatty acids and types of phospholipids in the lipid species significantly changed in response to PB.

From: An integrated functional genomic study of acute phenobarbital exposure in the rat

 

Day 3

 

Day 7

 

Day 14

 

Change with increasing dose of PB

Relative increase

Relative decrease

Relative increase

Relative decrease

Relative increase

Relative decrease

14:0

0 (0/0/0)

0 (0/0/0)

0 (0/0/0)

0 (0/0/0)

0 (0/0/0)

1 (1/0/0)

16:0

11 (0/2/9)

7 (0/0/7)

3 (0/0/3)

18 (1/2/15)

10 (0/2/8)

18 (1/3/14)

16:1

2 (1/0/1)

0 (0/0/0)

0 (0/0/0)

1 (0/0/1)

0 (0/0/0)

3 (0/1/2)

17:0

0 (0/0/0)

2 (1/0/1)

0 (0/0/0)

2 (1/0/1)

0 (0/0/0)

0 (0/0/0)

18:0

19 (1/5/13)

12 (0/0/12)

18 (1/2/15)

13 (0/0/13)

20 (1/4/15)

15 (0/2/13)

18:1

6 (1/0/5)

5 (0/1/4)

4 (1/0/3)

5 (0/0/5)

4 (1/1/2)

7 (0/0/7)

18:2

7 (1/1/5)

2 (0/0/2)

6 (1/1/4)

6 (0/1/5)

5 (1/1/3)

5 (0/0/5)

18:3

1 (1/0/0)

0 (0/0/0)

0 (0/0/0)

1 (0/0/1)

0 (0/0/0)

1 (0/0/1)

19:0

0 (0/0/0)

1 (0/0/1)

0 (0/0/0)

1 (0/0/1)

0 (0/0/0)

0 (0/0/0)

20:0

0 (0/0/0)

1 (1/0/0)

0 (0/0/0)

1 (1/0/0)

0 (0/0/0)

1 (1/0/0)

20:1

1 (0/0/1)

0 (0/0/0)

1 (0/0/1)

1 (1/0/0)

1 (0/0/1)

2 (1/1/0)

20:2

1 (0/0/1)

2 (0/0/2)

1 (0/0/1)

2 (0/0/2)

1 (0/0/1)

3 (0/1/2)

20:3

2 (1/0/1)

3 (0/1/2)

4 (1/1/2)

4 (0/1/3)

3 (1/0/2)

3 (0/0/3)

20:4

0 (0/0/0)

11 (0/1/10)

1 (0/0/1)

15 (1/2/12)

4 (0/1/3)

9 (0/1/8)

20:5

2 (1/1/0)

2 (0/1/1)

1 (1/0/0)

2 (0/1/1)

2 (1/1/0)

2 (0/1/1)

22:0

0 (0/0/0)

1 (1/0/0)

0 (0/0/0)

1 (1/0/0)

0 (0/0/0)

1 (1/0/0)

22:1

0 (0/0/0)

1 (0/1/0)

0 (0/0/0)

0 (0/0/0)

0 (0/0/0)

1 (0/1/0)

22:4

1 (0/0/1)

1 (1/0/0)

1 (0/0/1)

1 (1/0/0)

2 (0/0/2)

1 (1/0/0)

22:5

2 (0/1/1)

3 (0/0/3)

2 (0/0/2)

3 (0/0/3)

3 (0/0/3)

3 (0/0/3)

22:6

2 (0/0/2)

5 (0/0/5)

3 (0/0/3)

5 (0/0/5)

4 (0/0/4)

6 (0/1/05)

GpIns

13 (0/4/9)

2 (0/0/2)

12 (0/3/9)

4 (0/1/3)

22 (0/5/17)

0 (0/0/0)

GpEtn

1 (0/0/1)

12 (0/2/10)

0 (0/0/0)

20 (0/3/17)

0 (0/0/0)

22 (0/5/17)

GpCho

4 (0/1/3)

9 (0/1/8)

5 (0/1/4)

9 (0/0/9)

3 (0/0/3)

12 (0/2/10)

GpGro

6 (0/0/6)

2 (0/0/2)

5 (0/0/5)

2 (0/0/2)

1 (0/0/1)

2 (0/0/2)

GpSer

0 (0/0/0)

2 (0/0/2)

0 (0/0/0)

2 (0/0/2)

0 (0/0/0)

2 (0/0/2)

GPA

5 (0/5/0)

3 (0/2/1)

0 (0/0/0)

4 (0/3/1)

6 (0/5/1)

5 (0/5/0)

  1. Values are given as: total (fatty acid/monoacylphospholipids/diacylphospholipids). For example, at day 14 eighteen species containing 16:0 were decreased with increasing dose of PB and this can be broken down into the free fatty acid, 3 monoacylphospholipids and 14 diacylphospholipids (1/3/14).