Figure 4

Reconstruction of pathways involved in the central metabolism of C. aurimucosum ATCC 700975. The metabolic reconstruction of the carbohydrate metabolism was facilitated by using manually curated pathway maps in conjunction with the bioinformatics tool CARMEN. The resulting reconstruction was visualized with the CellDesigner software (version 3.2). Genes encoding transporters or enzymes involved in carbohydrate uptake and metabolism are shown in yellow boxes. Key metabolites are indicated by purple circles. Abbreviations for metabolites are as follows: α-Keto-G, α-ketoglutarate; β-Glcs, β-glycoside; 1,3PP-Gly, glycerate-1,3-bisphosphate; 2P-Gly, 2-phosphoglycerate; 3P-Gly, 3-phosphoglycerate; 5P-Ri-1PP, 5-phospho-ribose-1-diphosphate; 6P-β-Glcs, 6-phospho-β-glycoside; 6P-Gct, 6-phosphogluconate; 6P-Gll, 6-phosphogluconolactone; Aacetyl-CoA, acetoacetyl-CoA; Acetyl-P, acetyl-phosphate; CDP-ME, 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol; CDP-ME2P, 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol; CHM, 5-carboxymethyl-2-hydroxy-muconic acid; CHMS, 5-carboxymethyl-2-hydroxy-muconic semialdehyde; DHA, dihydroxyacetone; DHAP, dihydroxyacetone phosphate; DMAPP, dimethylallyl diphosphate; DXP, 1-deoxy-D-xylulose 5-phosphate; Ery-4P, erythrose-4-phosphate; FattyA-CoA, fatty acyl-CoA; Fru-1,6PP, fructose-1,6-bisphosphate; Fru-1P, fructose-1-phosphate; Fru-6P, fructose-6-phosphate; GA-3P, glyceraldehyde-3-phosphate; Gal-1P, galactose-1-phosphate; Glc-1P, glucose-1-phosphate; Glc-6P, glucose-6-phosphate; GlcNAc, N-acetylglucosamine; GlcNAc-6P, N-acetylglucosamine-6-phosphate; Glu-6P, glucosamine-6-phosphate; Glycerol-3P, glycerol-3-phosphate; GPDE, glycerophosphodiester; HHDD, 2-hydroxy-hept-2,4-diene-1,7-dioic acid; HHED, 2,4-dihydroxy-hept-2-ene-1,7-dioic acid; HMBDP, 1-hydroxy-2-methyl-2-butenyl 4-diphosphate; HPC, homoprotocatechuate; IPP, isopentenyl diphosphate; Man-1P, mannose-1-phosphate; Man-6P, mannose-6-phosphate; ManNAc-6P, N-acetyl-mannosamine-6-phosphate; MECDP, 2-C-methyl-D-erythritol 2,4-cyclodiphosphate; MEP, 2-C-methyl-D-erythritol 4-phosphate; OHED, 2-oxo-hept-3-ene-1,7-dioic acid; OPET, 5-oxo-pent-3-ene-1,2,5-tricarboxylic acid; PEP, phosphoenolpyruvate; Ribose-5P, ribose-5-phosphate; Sed-7P, sedoheptulose-7-phosphate; Ribu-5P, ribulose-5-phosphate; Suc-CoA, succinyl-CoA; Sucrose-6P, sucrose-6-phosphate; Sucsemiald, succinate semialdehyde; Tre-6P, trehalose-6-phosphate; UDP-Gal, UDP-galactose; UDP-Glc, UDP-glucose; Xyu-5P, xylulose-5-phosphate.