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Figure 5 | BMC Genomics

Figure 5

From: Statistics of protein-DNA binding and the total number of binding sites for a transcription factor in the mammalian genome

Figure 5

Validation of ChIP-seq defined c-Myc binding loci based on motif finding analysis. A: PWM of c-Myc TFBSs defined with NestedMICA program trained with 12 peak height or higher value defined in ChIP-seq experiment. B: Distribution of E-box sequences in ± 1 kb from the centre of ChIP-seq defined binding loci. C: Frequency distribution of the number of ChIP-seq overlapped DNA fragments (peak height). ◊: All ChIP-seq c-Myc bound loci for observed peak heights. o: E-boxes positive loci found in vicinity ± 250 bp. ∇: E-boxes positive loci found in vicinity ± 150 bp. D: Venn diagram of co-occurrence of E-boxes in ± 150 bp of c-Myc binding loci (left side). Pair of Kappa correlation coefficient of co-occurrence of E-boxes in c-Myc binding loci (right side).

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