Table 2 TGDP function parameters for the eleven TF libraries. Non-linear regression module of SigmaPlot program was used to estimate parameters of GDP function. More details regarding binding statistics and TGDP function parameters are presented in Definitions, Methods and Additional files.
TF | GDP-defined specificity threshold t |
| J | k± SE | β± SE | # GDP-predicted seq., | #Observed seq. at GDP specificity threshold t, M2 |
|
|---|---|---|---|---|---|---|---|---|
Esrrb | 12 | 21646 | 338 | 2.40 ± 0.077 | 10.42 ± 0.682 | 570938 | 551406 | 1.04 |
Nanog | 11 | 10343 | 312 | 1.81 ± 0.156 | 8.00 ± 1.33 | 297493 | 299830 | 0.99 |
Oct4 | 11 | 1697 | 195 | 3.00 ± 0.494 | 7.66 ± 2.910 | 34153 | 30637 | 1.11 |
sox2 | 13 | 2082 | 206 | 2.35 ± 0.225 | 3.03 ± 1.432 | 49976 | 44023 | 1.14 |
E2f1 | 16 | 13741 | 399 | 3.55 ± 0.006 | 46.24 ± 0.340 | 553688 | 517826 | 1.07 |
Tcfcp2I1 | 17 | 16293 | 382 | 1.50 ± 0.077 | 9.28 ± 1.227 | 771652 | 839103 | 0.92 |
Zfx | 11 | 7161 | 197 | 2.90 ± 0.162 | 3.73 ± 0.778 | 129813 | 123943 | 1.05 |
Klf4 | 10 | 7433 | 184 | 4.83 ± 0.335 | 11.16 ± 1.421 | 112898 | 107891 | 1.05 |
c-Myc | 12 | 1980 | 132 | 2.94 ± 0.742 | 16.24 ± 7.298 | 47030 | 44402 | 1.06 |
n-Myc | 13 | 3214 | 119 | 2.81 ± 0.228 | 4.01 ± 1.306 | 68725 | 65302 | 1.05 |
STAT 3 | 11 | 1229 | 173 | 4.02 ± 0.650 | 16.19 ± 4.248 | 24209 | 22635 | 1.07 |
at t