TY - JOUR AU - Karpov, Pavel A. AU - Nadezhdina, Elena S. AU - Yemets, Alla I. AU - Matusov, Vadym G. AU - Nyporko, Alexey Yu AU - Shashina, Nadezhda Yu AU - Blume, Yaroslav B. PY - 2010 DA - 2010/02/10 TI - Bioinformatic search of plant microtubule-and cell cycle related serine-threonine protein kinases JO - BMC Genomics SP - S14 VL - 11 IS - 1 AB - A bioinformatic search was carried for plant homologues of human serine-threonine protein kinases involved in regulation of cell division and microtubule protein phosphorylation (SLK, PAK6, PAK7, MARK1, MAST2, TTBK1, TTBK2, AURKA, PLK1, PLK4 and PASK). A number of SLK, MAST2 and AURKA plant homologues were identified. The closest identified homologue of human AURKA kinase was a protein of unknown function, A7PY12/GSVIVT00026259001 from Vitis vinifera (herein named as "STALK", Serine-Threonine Aurora-Like Kinase). Analysis of STALK's three-dimensional structure confirmed its relationship to the subgroup of AURKA-like protein kinases. SN - 1471-2164 UR - https://doi.org/10.1186/1471-2164-11-S1-S14 DO - 10.1186/1471-2164-11-S1-S14 ID - Karpov2010 ER -