Parameterization of disorder predictors for large-scale applications requiring high specificity by using an extended benchmark dataset

Table 10 Estimated disorder frequencies in the human proteome with IUPred long.

IUPred long threshold	minimum length to consider region as disordered	% of sequences with disorder	% of disordered residues
0.50	0	82.6	26.7
0.50	10	62.0	22.8
0.50	30	38.8	17.5
0.54	0	78.8	23.3
0.54	10	57.3	19.7
0.54	30	34.9	14.9

A subset with 56915 non-redundant sequences (< 98% identity) from the human IPI v3.54 database was used to estimate frequencies of disordered residues and sequences with disorder predicted by IUPred long at different thresholds (0.5 ... default; 0.54 ... estimated 5% false positive rate)

ISSN: 1471-2164