Figure 3

Members of the TNFAIP1/POLDIP2 CSAGA are mutually co-regulated in breast cancer and form a structural--functional gene module. Correlation matrices visually demonstrate the presence of a characteristic co-regulatory pattern: the co-regulatory area is formed by enrichment of significant Pearson correlation coefficients (α = 1%). Members of the TNFAIP1/POLDIP2 CSAGA form a SFGM (blue matrix - SFGM matrix); the light green matrix shows correlations among six 'neighbouring' genes (the 'neighbouring' genes matrix - NG matrix); the light violet matrix area marks intergroup correlations between genes of the SFGM matrix and NG matrix.. A, C and E -- Uppsala cohort; B, D and F -- Stockholm cohort; A and B -- correlation matrices, C and D - individual gene expression in breast cancer patients in different breast cancer grades (G1, G1-like, G3-like and G3 [16]), E and F - heat map visualization of gene expression in different grades of breast cancer.