Effector prediction in host-pathogen interaction based on a Markov model of a ubiquitous EPIYA motif

Table 1 Experimentally determined tyrosine-phosphorylated effectors and their motifs

Effector	Pathogen	Locus of protein	Motif (phosphorylated Y position)
CagA	H.Ppylori	NP_207343	EPIYAKVNK	Y-899	EPIYTQVAK	Y-918	EPIYATIDD	Y-972
Ankyrin	Anaplasma phagocytophilum	ABB84853	ESIYEEIKD	Y-940	ESIYEEIKD	Y-967	ESIYEEIKD	Y-994
EDLYATVGA	Y-1028	ESIYADPFD	Y-1056	ESIYADPFA	Y-1074
EPIYATVKK	Y-1098
BepD	Bartonella henselae	YP_034066	EPLYAQVNK	Y-32	NPLYEGVGG	Y-114	NPLYEGVGS	Y-176
EPLYAQVNK	Y-211	NPLYEGVGG	Y-293	NPLYEGVGP	Y-355
BepE	Bartonella henselae	YP_034067	EPLYATVNK	Y-37	ETIYTTVSS	Y-91
BepF	Bartonella henselae	YP_034068	TPLYATPSP	Y-149	EPLYATPLP	Y-213	EPLYATPLP	Y-241
EPLYATAAP	Y-297	EPLYATPLP	Y-269
Tir	Escherichia Eoli	AAC38390	EHIYDEVAA	Y-474
Tir	Citrobacter rodentium	AAL06376	EPIYDEVAP	Y-468
Trap	Chlamydie trachomatis	YP_001654788	ENIYENIYE	Y-136	ENIYENIYE	Y-238	ENIYENIYE	Y-390

CagA: cytotoxin associated gene A[7, 8, 10, 52–56]; BepD: Bartonella henselae protein D[14–16, 57]; BepE: Bartonella henselae protein E[14–16, 57]; BepF: Bartonella henselae protein F[14–16, 57]; Tir: translocated intimin receptor[58–60]; Trap: Translocated actin-recruiting protein[61–63]. The first five amino acids of the listed sequences in the table correspond to the EPIYA motif.