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Table 1 Experimentally determined tyrosine-phosphorylated effectors and their motifs

From: Effector prediction in host-pathogen interaction based on a Markov model of a ubiquitous EPIYA motif

Effector Pathogen Locus of protein Motif (phosphorylated Y position)
CagA H.Ppylori NP_207343 EPIYAKVNK Y-899 EPIYTQVAK Y-918 EPIYATIDD Y-972
Ankyrin Anaplasma phagocytophilum ABB84853 ESIYEEIKD Y-940 ESIYEEIKD Y-967 ESIYEEIKD Y-994
EDLYATVGA Y-1028 ESIYADPFD Y-1056 ESIYADPFA Y-1074    
EPIYATVKK Y-1098        
BepD Bartonella henselae YP_034066 EPLYAQVNK Y-32 NPLYEGVGG Y-114 NPLYEGVGS Y-176
EPLYAQVNK Y-211 NPLYEGVGG Y-293 NPLYEGVGP Y-355    
BepE Bartonella henselae YP_034067 EPLYATVNK Y-37 ETIYTTVSS Y-91   
BepF Bartonella henselae YP_034068 TPLYATPSP Y-149 EPLYATPLP Y-213 EPLYATPLP Y-241
EPLYATAAP Y-297 EPLYATPLP Y-269      
Tir Escherichia Eoli AAC38390 EHIYDEVAA Y-474     
Tir Citrobacter rodentium AAL06376 EPIYDEVAP Y-468     
Trap Chlamydie trachomatis YP_001654788 ENIYENIYE Y-136 ENIYENIYE Y-238 ENIYENIYE Y-390
  1. CagA: cytotoxin associated gene A[7, 8, 10, 5256]; BepD: Bartonella henselae protein D[1416, 57]; BepE: Bartonella henselae protein E[1416, 57]; BepF: Bartonella henselae protein F[1416, 57]; Tir: translocated intimin receptor[5860]; Trap: Translocated actin-recruiting protein[6163]. The first five amino acids of the listed sequences in the table correspond to the EPIYA motif.