A comparative study of cancer proteins in the human protein-protein interaction network

BMC Genomics

Table 1 Summary of network properties for five protein sets in the human interactome

Protein set	No. of genes	No. of proteins^a	Network properties (average value)
Connectivity	Betweenness (10⁴)	Clustering coefficient	gSPD^b	cSPD^c
Cancer proteins	382	342	25.41	6.29	0.13	3.63	3.20
Essential proteins	2217	1896	18.39	4.16	0.14	3.76	3.55
Control proteins	8402	8402	8.25	1.47	0.19	3.99	4.10
Recessive cancer proteins	72	69	33.03	9.82	0.13	3.61	3.05
Dominant cancer proteins	310	273	23.44	5.33	0.13	3.64	3.21

^aNumber of genes whose proteins could be found in the human interactome.
^bGeneral shortest-path distance between the interest proteins and the remaining proteins in thewhole network.
^cCharacteristic shortest-path distance among the interest proteins in the whole network.

ISSN: 1471-2164