Figure 5From: Probing the anticancer mechanism of prospective herbal drug Withaferin A on mammals: a case study on human and bovine proteasomesPositioning of WA in the docked structure of h20S. Lactone ring of WA positions itself quite close to the hydroxyl group of Thr1 of h20S receptor thus making itself prone to the nucleophilic attack by Thr1 of β-5 subunit.Back to article page