Exploring hierarchical and overlapping modular structure in the yeast protein interaction network

BMC Genomics

Table 1 Comparison of ADHOC to Competing Clustering Methods for DIP Yeast PPI Dataset

Method	Cluster Number	Cluster Size	Discard (%)	GO (-log P-value)
				MF	BP	CC
ADHOC	50	20.56	68.05	5.18	7.44	6.38
Maximal Clique	376	4.55	80.06	3.43	4.02	2.67
IPCA	253	4.64	80.39	3.61	4.09	2.89
DPClus	90	5.27	84.49	3.91	4.50	3.44
MCODE	29	23.76	75.21	4.20	5.23	4.89
CFinder	84	7.46	80.06	4.63	6.03	4.66

Cluster Number: the number of clusters identified by each method; Cluster Size: the average number of proteins in each cluster; Discard (%): the percentage of proteins not assigned to any cluster; GO: the average -log p-values (adjusted) of all detected clusters for Gene Ontology (molecular functions (MF), biological process (BP), and cellular component (CC)).

ISSN: 1471-2164