The interplay between evolution, regulation and tissue specificity in the Human Hereditary Diseasome

BMC Genomics

Table 1 Summary of the overall gene based datasets analysed during this analysis. The numbers shown in the table represents the genes in respective categories.

	1. Age		2. Specificity		3. Expression		4. Interactions		5. Disease		6. Tr. Factor		7. PTM		9. Sequence
	OLD	NEW	TSP	HKP	EXL	EXH	INT	NIN	DIS	NDI	TFA	NTF	PTM	NPT	SHO	LON
OLD	8301		2424	2648	2587	2485	3445	4856	1892	6409	650	7651	1310	6991	3362	4939
NEW		4452	1204	700	1012	892	1213	3239	630	3822	349	4103	475	3977	3020	1432
TSP			3628		2619	1009	1571	2057	879	2749	304	3324	582	3046	1719	1909
HKP				3348	980	2368	1783	1565	848	2500	347	3001	737	2611	1144	2204
EXL					3599		1543	2056	830	2769	342	3257	565	3034	1512	2087
EXH						3377	1811	1566	897	2480	309	3068	754	2623	1351	2026
INT							4658		1524	3134	573	4085	1335	3323	1963	2695
NIN								8095	998	7097	426	7669	450	7645	4419	3676
DIS									2522		262	2260	607	1915	988	1534
NDI										10231	737	9494	1178	9053	5394	4837
TFA											999		228	771	493	506
NTF												11754	1557	10197	5889	5865
PTM													1785		668	1117
NPT														10968	5714	5254
REG															1090	1466
NRE															5292	4905
SHO															6382
LON																6371

Abbreviations: OLD: Old gene (ps1 and ps2); NEW: New genes (ps3 to ps19); TSP: Tissue specific genes; HKP: House Keeping genes; EXL: Expression Low; Expression High; INT: Interacting genes; NIN: Non-interacting genes; DIS: Disease-associated genes; NDIS: Non disease associated genes; TFA: Transcription Factors; NTF: Non-transcription Factors; PTM: Genes with at least one post-translational modification; NPT: Genes with no post-translational modification; LONG: Genes longer than 24kb in length; REG: Genes with regulatory role TF and/orPTM; NRE: Non-regulatory genes. SHO: Genes shorter than 24kb in length.

ISSN: 1471-2164