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Figure 5 | BMC Genomics

Figure 5

From: Inhibition of the NEMO/IKKβ association complex formation, a novel mechanism associated with the NF-κB activation suppression by Withania somnifera’s key metabolite withaferin A

Figure 5

H-bonding interactions present in the docked complex of withaferin A with active NEMO/IKKβ complex using flexible docking. Polar hydroxyl terminal group of withaferin A captivates hydroxyl group of SER 733 to form H-bond with itself, thus disrupting the earlier present SER 733 - GLU 89 H-bond.

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BMC Genomics

ISSN: 1471-2164

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