Tumor and reproductive traits are linked by RNA metabolism genes in the mouse ovary: a transcriptome-phenotype association analysis

Table 1 Ovarian tumor and reproductive phenotypes in selected mouse strains

Strain	Tumor frequency^a	Litter size^b	Number of litters	Productive matings (%)	Relative fecundity
BALB/c	3.80	4.9	3.6	55.6	9.80
C57BL/6	1.60	6.6	3.8	87.4	21.9
FVB^c	7.00	9.5	4.8	90.0	41.0
SWR	57.0	7.5	2.3	58.3	10.1

^a Refers to spontaneously arisen tumors in inbred mice. Data corresponds to the “highest reported tumor frequency” in all literature records collected in the Mouse Tumor Biology Database [9], (http://tumor.informatics.jax.org/mtbwi/dynamicGrid.do;jessession=89370725979E9B939D3DD40AB4961BA5) for each strain/organ combination where organ=ovary.
^b Litter size, number of litters, and productive matings were taken from the Mouse Phenome Database [8] (http://www.jax.org/phenome). Data acquisition, curation and handling are described at http://phenome.jax.org/db/q?rtn=docs/aboutmpd. The parameter “relative fecundity” is derived form the other 3 reproductive parameters [5].
^c Data of FVB strain was taken from Silver’s Mouse Genetics textbook [5].

ISSN: 1471-2164