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Figure 4 | BMC Genomics

Figure 4

From: RNA interference-mediated knockdown of CD49e (α5 integrin chain) in human thymic epithelial cells modulates the expression of multiple genes and decreases thymocyte adhesion

Figure 4

Classification of genes differentially expressed by human thymic epithelial cells after treatment with CD49e-siRNA versus scramble-siRNA. The figure shows that most of genes up- or down-regulated in cultured human TEC under treatment with CD49e-siRNA (as compared to scramble-siRNA) are not annotated. Yet, among the down-regulated genes with defined functions, 6% code for adhesion molecules. Additionally, a large number of genes related to signal transduction was modulated in CD49e silenced TEC: among those genes whose expression was down-regulated they represented 9%, and corresponded to 23% of the whole amount of up-regulated genes. The classification of 65 down and 66 up-regulated genes in silenced cells to biological functions is given in left and right panels, respectively. The classification into functional categories was defined according to the NCBI, SOURCE (http://smd.stanford.edu/cgi-bin/source/sourceSearch) and DAVID (http://david.abcc.ncifcrf.gov/) databases.

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BMC Genomics

ISSN: 1471-2164

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