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Table 5 List of the human genes in the INHGI with the 10 highest druggability scores

From: A machine learning approach for genome-wide prediction of morbid and druggable human genes based on systems-level data

Gene

  

Druggability score

  

(Median [min,max])1

  

N

  

W

W c 2 (two-tailed p = 0.05)

Druggability evidence3

   

Normal

  

Shuffled

    

HLA-F

  

0.887[0.803,0.915]

  

0.530[0.427,0.584]

  

10

  

0

8*

No evidence

PLAU4

  

0.886[0.808,0.907]

  

0.561[0.387,0.675]

  

10

  

0

8*

19301652

CD8A4

  

0.885[0.871,0.902]

  

0.56[0.37,0.664]

  

10

  

0

8*

No evidence

CD194

  

0.880[0.751,0.907]

  

0.562[0.38,0.628]

  

10

  

0

8*

19509168

ITGAM4

  

0.878[0.614,0.887]

  

0.534[0.36,0.656]

  

10

  

1

8*

11931348

THBS15

  

0.875[0.53,0.9]

  

0.532[0.293,0.592]

  

10

  

0

8*

17878288

ITGAX

  

0.873[0.784,0.897]

  

0.539[0.422,0.691]

  

10

  

0

8*

No evidence

CXCR5

  

0.871[0.755,0.895]

  

0.537[0.49,0.59]

  

10

  

0

8*

17652619

EBI3

  

0.871[0.801,0.888]

  

0.529[0.391,0.626]

  

10

  

0

8*

19556516

IL64

  

0.87[0.766,0.893]

  

0.591[0.361,0.643]

  

10

  

0

8*

17465721

TIMP25

  

0.869[0.645,0.916]

  

0.584[0.34,0.701]

  

10

  

0

8*

10985804

  1. 1 Of 10 scores
  2. 2 According to table of critical values for W in [6]
  3. 3 Pudmed IDs of most recent articles clearly stating that such genes may be drug target candidates
  4. 4 Morbid genes according to Morbid Map [46]
  5. 5 Genes among those with 10 highest morbidity scores (Table 4)
  6. * Difference statistically significant
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BMC Genomics

ISSN: 1471-2164

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