The SOX2 response program in glioblastoma multiforme: an integrated ChIP-seq, expression microarray, and microRNA analysis

Table 1 GO terms that are enriched in SOX2 binding genes identified by ChIP-seq

GO CATEGORY	TOTAL GENES	Changed Genes	Enrichment folds	P value (Log10)	FDR
GO:0005096_GTPase_activator_activity	60	27	2.39	-5.54	0.01
GO:0004871_signal_transducer_activity	792	196	1.31	-5.17	0.003333
GO:0060089_molecular_transducer_activity	792	196	1.31	-5.17	0.003333
GO:0060090_molecular_adaptor_activity	48	20	2.21	-3.69	0.0175
GO:0022843_voltage-gated_cation_channel_activity	66	25	2.01	-3.67	0.014
GO:0008066_glutamate_receptor_activity	20	11	2.92	-3.50	0.016667
GO:0004872_receptor_activity	562	137	1.29	-3.41	0.02
GO:0005070_SH3_SH2_adaptor_activity	43	18	2.22	-3.40	0.02
GO:0004672_protein_kinase_activity	278	75	1.43	-3.37	0.017778
GO:0005001_transmembrane_receptor_protein_tyrosine_phosphatase_activity	18	10	2.95	-3.27	0.019091
GO:0019198_transmembrane_receptor_protein_phosphatase_activity	18	10	2.95	-3.27	0.019091
GO:0005099_Ras_GTPase_activator_activity	28	13	2.47	-3.11	0.023333
GO:0030695_GTPase_regulator_activity	124	38	1.63	-3.02	0.023077
GO:0016301_kinase_activity	365	92	1.34	-2.92	0.027143
GO:0042805_actinin_binding	4	4
GO:0008092_cytoskeletal_protein_binding	164	47	1.52	-2.89	0.026667
GO:0016773_phosphotransferase_activity__alcohol_group_as_acceptor	326	83	1.35	-2.82	0.029375
GO:0004888_transmembrane_receptor_activity	410	101	1.31	-2.80	0.029412
GO:0005244_voltage-gated_ion_channel_activity	76	25	1.75	-2.63	0.035263
GO:0022832_voltage-gated_channel_activity	76	25	1.75	-2.63	0.035263
GO:0030674_protein_binding__bridging	58	20	1.83	-2.47	0.0455

ISSN: 1471-2164