Figure 2

Screenshot of the 'Map' graphical display of TRAM software (detail). The length of each horizontal bar is proportional to the mean gene expression within a chromosomal segment of 0.5 Mb. Consecutive bars are shifted by 250 kb. The vertical line represents human chromosome 4, from position 64,750,001 (start of the top segment) to position 76,750,000 (end of the bottom segment). The expression value on the left of each bar is derived from the analysis of the test set used (Table 1). Bars are colour-coded in proportion to their expression values. Segments, whose expression value is greater (or lower) than the chosen percentile threshold, are highlighted in the "Over/Under" field, which is only filled when they also include the user-defined minimum number of over/under-expressed genes that must be present in the segment. Statistical significance p- and q-values are calculated for these regions.