Figure 1From: Widespread, focal copy number variations (CNV) and whole chromosome aneuploidies in Trypanosoma cruzi strains revealed by array comparative genomic hybridizationRepresentative plots from 12 hybridizations for T. cruzi chromosome 39. Each dot represents an oligonucleotide probe. The CL-Brener strain, which was used as the reference strain for genome sequencing, is hybrid, thus probes were designed to non-Esmeraldo (non-Esm) sequences (blue spots), Esmeraldo-like (Esm) sequences (green spots), non-Esm gene family sequences (black spots), and Esm gene family sequences (gray spots). In each panel positive log2 ratios of signal intensities (test strain/reference strain) represent amplification in the test strain and negative log2 ratios represent deletion in the test strain, relative to CL-Brener, which was the reference strain in all hybridizations. Shown are examples of segmental aneuploidies of different sizes boxed in gray (>500 kbp amplification in Brazil strain relative to CL-Brener -arrow) and red (~40 kbp deletion in several strains). The Esmeraldo hybridization (boxed in orange) shows decreased log2ratios for the non-Esm probes (blue) and increased log2ratios for the Esm probes (green), as expected because Esmeraldo is homozygous for the Esm haplotype.Back to article page