Gene expression analyses of immune responses in Atlantic salmon during early stages of infection by salmon louse (Lepeophtheirus salmonis) revealed bi-phasic responses coinciding with the copepod-chalimus transition

Table 1 Enrichment of GO classes and KEGG pathways in the lists of DEG

Functional group, pathway	Features¹	p-value²	Vocabulary
*Skin*
Mitochondrion	177 / 1104	0.000	GO
Glycolysis / Gluconeogenesis	33 / 117	0.000	KEGG
Pentose phosphate pathway	13 / 48	0.009	KEGG
Glutamate metabolism	16 / 48	0.000	KEGG
Glutathione metabolism	13 / 49	0.011	KEGG
Ribosome	47 / 172	0.000	GO
Protein folding	33 / 178	0.015	GO
Protein modification	44 / 246	0.009	GO
Protein transport	78 / 473	0.004	GO
Cytoskeleton	89 / 579	0.013	GO
Myosin complex	23 / 86	0.000	GO
Endoplasmic reticulum	140 / 992	0.027	GO
Cell redox homeostasis	11 / 43	0.027	GO
Double-strand break repair	7 / 24	0.050	GO
Anti-apoptosis	41 / 200	0.001	GO
Positive regulation of apoptosis	12 / 51	0.037	GO
Antigen processing and presentation ³	17 / 69	0.007	KEGG
Leukocyte transendothelial migration	32 / 186	0.043	KEGG
Cell adhesion	83 / 545	0.020	GO
Tight junction	38 / 208	0.011	KEGG
Heparin binding	18 / 90	0.043	GO
Keratinization	8 / 21	0.006	GO
TGF-beta signaling pathway	24 / 113	0.008	KEGG
*Spleen*
Inflammatory response	22 / 213	0.000	GO
Complement and coagulation cascades	29 / 85	0.000	KEGG
Peptidase activity	23 / 145	0.000	GO
Acute-phase response	8 / 20	0.000	GO
Chemotaxis	10 / 81	0.003	GO
Basement membrane	10 / 68	0.000	GO
Cell adhesion	36 / 545	0.020	GO
Extracellular space	47 / 375	0.000	GO
Heparin binding	13 / 90	0.000	GO
Neuroactive ligand-receptor interaction	14 / 173	0.036	KEGG

¹ Numbers of genes among DEG and on the microarray platform. ²Yates' corrected chi-square. ³Immune related groups and pathways are highlighted with bold.

ISSN: 1471-2164