Figure 1

Genome-wide mapping of C/EBPα and PPARγ binding in human SGBS adipocytes. (A) The number of C/EBPα and PPARγ sites in SGBS and 3T3-L1 adipocytes. Results are shown as Venn diagrams representing the number of binding sites for C/EBPα only (blue), PPARγ only (red), and overlapping binding sites (purple). (B) Expression clusters of genes based on their changes in RNAPII occupancy during 3T3-L1 adipogenesis. The clusters correspond to genes that are (1) downregulated, (2) transiently upregulated, (3) moderately upregulated or (4) highly upregulated. (C) Distribution of PPARγ sites relative to TSS of downregulated genes (magenta), transiently upregulated genes (yellow), moderately upregulated genes (green), highly upregulated genes (blue) and randomly selected regions (purple), in mouse and human. The region +/- 100 kb around each TSS was divided into 10 kb regions, and the mean number of sites in each region is indicated in the bar plots.