Figure 4
From: Comparative transcriptome profiling of amyloid precursor protein family members in the adult cortex
Co-regulation of genes in WT/APP-/- and WT/APLP2-/-. (a) Overview of the analyzed comparisons. (b) Venn diagram of the two comparisons WT/APP-/- and WT/APLP2-/- based on gene lists obtained by significance analysis. The number of significant genes is indicated in the respective segments. Note that 181 genes are co-regulated by the lack of either APP or APLP2. (c) Heatmap of the 213 identifiers corresponding to the set of 181 genes that are co-regulated in both pairwise comparisons. All identifiers show differential expression in the same direction. (d) Heatmap of 122 identifiers corresponding to the set of 97 genes that are found in both pairwise comparisons as well as in WT/APPα/α. The values of the heatmaps (c,d) are normalized expression values with red and blue color representing the number of standard standard deviations above or below the mean expression for each probe set, respectively.