Figure 6

Analysis of common genetic profiles in WT/APP^-/-, WT/APP^α/α and APP^α/α/APP^-/-. (a) Overview of the analyzed comparisons. (b) Venn diagram with SAM-based gene lists of the three comparisons WT/APP^-/-, WT/APP^α/α and APP^α/α/APP^-/-. The numbers indicate the absolute number of differentially expressed genes in the respective comparison. (c) Percentage of probe set identifiers co-regulated in two or three pairwise comparisons. Values are based on the 200 most significantly differentially expressed identifiers for each pairwise comparison. Note that 40% of probe sets are found in the overlap between WT/APP^-/- and WT/APP^α/α. (d) Heatmap of the probe set identifiers corresponding to the set of 6 genes (b) in the intersection of WT/APP^α/α, APP^α/α/APP^-/-. The values of the heatmap are normalized expression values with red and blue color representing the number of standard standard deviations above or below the mean expression for each probe set, respectively.