Figure 8
From: Comparative transcriptome profiling of amyloid precursor protein family members in the adult cortex
Co-regulation of genes in WT(R6)/APLP2(R6)-/-, WT(R6)/APLP2(R1)-/-, APLP2(R6)-/-/APLP2(R1)-/-. (a) Overview of the analyzed comparisons. (b) Percentage of probe set identifiers co-regulated in two or three pairwise comparisons. Values are based on the 200 most significantly differentially expressed identifiers for each pairwise comparison. (c) Venn diagram with SAM-based gene lists of the three comparisons WT(R6)/APLP2(R6)-/-, WT(R6)/APLP2(R1)-/- and APLP2(R6)-/-/APLP2(R1)-/-. (d) Cluster analysis of probe sets corresponding to the set of 27 genes from (c) found exclusively in the comparisons WT(R6)/APLP2(R6)-/- and APLP2(R6)-/-/APLP2(R1)-/-. The values of the heatmap are normalized expression values with red and blue color representing the number of standard standard deviations above or below the mean expression for each probe set, respectively.