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Table 2 Module highlights

From: Stochastic variation of transcript abundance in C57BL/6J mice

  Module Data-base Functional Category In Module In Category Overlap % p-value c
Adipose turquoise GO_MF endopeptidase inhibitor activity 52 55 8 15 7E-25 0.44
  blue GO_BP epidermis development 184 40 12 30 3E-23 0.00
  brown GO_CC contractile fiber 450 56 39 70 2E-74 0.07
  gold GO_MF acyl group transferase activity 102 64 10 16 6E-19 0.12
  green GO_MF cytokine activity 147 53 15 28 6E-32 0.28
  red GO_BP Apoptosis 34 245 6 2 7E-06 0.42
  black GO_BP energy pathways 110 104 10 10 2E-09 0.00
  magenta GO_BP immune system process 1340 324 158 49 1E-34 0.00
Heart turquoise GO_BP inflammatory response 102 103 14 14 6E-21 0.17
  blue GO_BP anti-apoptosis 115 29 5 17 3E-10 0.20
  brown GO_CC antigen presentation, exogenous antigen 52 15 9 60 1E-75 0.03
  gold KEGG leukocyte activation 145 116 18 55 1E-25 0.00
  green GO_CC extracellular matrix 898 111 57 51 2E-26 0.00
  red GO_BP monosaccharide biosynthetic process 313 18 8 44 1E-13 0.00
  black GO_CC ubiquitin ligase complex 237 14 5 36 1E-10 0.00
  pink GO_CC mitochondrial membrane part 147 27 12 44 1E-55 0.00
Kidney turquoise GO_BP acute inflammatory response 146 46 17 37 1E-47 0.01
  blue GO_CC extracellular matrix 94 111 22 20 8E-51 0.42
  brown GO_MF carboxylic acid transmembrane transport 159 19 4 21 3E-07 0.58
  gold GO_BP antigen presentation, exogenous antigen 72 15 7 47 2E-56 0.57
  green GO_CC mitochondrial outer membrane 141 34 5 15 1E-06 0.59
  red GO_MF nucleoside-triphosphatase activity 46 159 4 3 4E-03 0.13
  black GO_BP fatty acid biosynthetic process 59 42 5 12 3E-12 0.10
  pink GO_BP down regulation of signal transduction 92 50 6 12 6E-12 0.69
  magenta KEGG oxidative phosphorylation 711 50 19 38 7E-08 0.00
Liver turquoise GO_CC Myofibril 70 54 9 17 2E-26 0.02
  blue GO_MF enzyme regulator activity 146 227 13 6 1E-03 0.77
  brown GO_CC extracellular matrix 112 111 13 12 2E-13 0.74
  gold GO_BP cholesterol biosynthetic process 101 18 6 33 5E-26 0.44
  green GO_MF selenium binding 395 14 5 36 7E-06 0.39
  red GO_BP cytokine-mediated signalling pathway 152 21 5 24 5E-10 0.72
  black GO_BP blood vessel development 138 109 9 8 2E-05 0.78
  pink GO_BP antigen presentation, exogenous antigen 69 15 6 40 4E-45 0.79
  magenta GO_BP ribosome biogenesis 176 22 5 23 1E-08 0.74
  1. Best enrichment scores of co-expression modules are shown. Within each tissue, modules are listed by the colour code orders of Figure 3. The number of genes in the module, the number of variable genes in the highest scoring functional category, the overlap between these two sets of genes, the enrichment p-value for the highest scoring category [11], and the median intraclass correlation, c, for genes in the module are shown. Only categories with between 10 and 500 genes and a minimum overlap of 4 genes were considered.