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Table 4 Genes in significant Gene Ontology categories of the biological processes

From: Modulation of gene expression in heart and liver of hibernating black bears (Ursus americanus)

GO category Gene Name Gene
Symbol
P value Fold Change
(Log2FC)
HEART     
Up-regulated    
Translation (GO:0006412) RNA binding motif protein 3 Rbm3 <0.001 2.863
  Ribosomal protein L35A Rpl35a <0.001 1.857
  Ribosomal protein S23 Rps23 0.001 1.793
  Ribosomal protein L7A Rpl7a 0.002 1.287
  Ribosomal protein L7 Rpl7 <0.001 1.243
  Eukaryotic translation elongation factor 1 beta 2 Eef1b2 0.001 1.187
  Ribosomal protein S3 Rps3 0.005 1.166
  Ribosomal protein L10A Rpl10a 0.003 1.156
  Eukaryotic translation initiation factor 5A Eif5a <0.001 1.147
  Ribosomal protein S15A Rps15a 0.008 1.116
  Ribosomal protein L27 Rpl27 0.003 1.099
  Lysyl-trna synthetase Kars <0.001 1.075
  Ribosomal protein S4, X-linked Rps4x 0.001 1.018
  Ribosomal protein S13 Rps13 0.003 1.012
  Ribosomal protein L30 Rpl30 0.002 1.010
  Ribosomal protein S24 Rps24 0.002 1.000
  Ribosomal protein, large, P0 Rplp0 0.001 0.936
  Ribosomal protein L27A Rpl27a 0.008 0.927
  Ribosomal protein L22 Rpl22 0.004 0.923
  Ribosomal protein L36A-like Rpl36al 0.005 0.917
  Ubiquitin A-52 residue ribosomal protein fusion product 1 Uba52 0.009 0.915
  Eukaryotic translation initiation factor 3, subunit G Eif3g 0.001 0.910
  Ribosomal protein L5 Rpl5 0.002 0.900
  Eukaryotic translation initiation factor 3, subunit F Eif3f 0.003 0.884
  Ribosomal protein L10A Rpl10 0.008 0.863
  Alanyl-trna synthetase domain containing 1 Aarsd1 0.006 0.838
  Ribosomal protein, large, P2 Rplp2 0.001 0.732
  Ribosomal protein L24 Rpl24 0.003 0.725
  Ribosomal protein S27 Rps27 0.001 0.720
  Eukaryotic translation initiation factor 2, subunit 3 gamma Eif2s3 0.004 0.668
  Density-regulated protein Denr 0.007 0.651
  Ribosomal protein L18A Rpl18a 0.002 0.607
LIVER     
Up-regulated    
Fatty acid beta-oxidation (GO:0006635) Acyl-Coenzyme A dehydrogenase, short/branched chain Acadsb 0.010 0.922
  Acyl-Coenzyme A dehydrogenase, very long chain Acadvl 0.001 0.842
  Hydroxyacyl-Coenzyme A dehydrogenase, beta subunit Hadhb 0.008 0.711
  Hydroxyacyl-Coenzyme A dehydrogenase, alpha subunit Hadha 0.007 0.586
  Acyl-Coenzyme A dehydrogenase, C-4 to C-12 straight chain Acadm 0.001 0.510
Translation (GO:0006412) Ribosomal protein L36 Rpl36 0.004 1.223
  Ribosomal protein L23 Rpl23 0.003 1.002
  Nascent polypeptide-associated complex alpha subunit Naca 0.001 1.182
  Eukaryotic translation elongation factor 1 delta Eef1d 0.001 1.170
  Translocated promoter region (to activated MET oncogene) Tpr <0.001 1.116
  Ribosomal protein S6 Rps6 0.010 1.079
  Ribosomal protein S20 Rps20 0.002 0.990
  Ribosomal protein L34 Rpl34 <0.001 0.929
  Ribosomal protein L9 Rpl9 0.005 0.829
  Ribosomal protein S16 Rps16 0.001 0.808
  Mediator complex subunit 8 Med8 0.004 0.683
  Ribosomal protein L28 Rpl28 0.001 0.617
  Protein kinase C, alpha Prkca 0.004 0.572
  Isoleucyl-trna synthetase Iars 0.007 0.565
Down-regulated    
Amino acid catabolic process (GO:0009063) Arginase, liver Arg1 0.009 -2.050
  Glutamic-oxaloacetic transaminase 1, soluble Got1 0.003 -1.287
  Coenzyme A carboxylase, beta polypeptide Pccb <0.001 -1.176
  Aldehyde dehydrogenase 6 family, member A1 Aldh6a1 0.006 -1.086
  Methylcrotonoyl-Coenzyme A carboxylase 2 (beta) Mccc2 0.001 -1.052
  Leucine aminopeptidase 3 Lap3 0.008 -0.943
  Branched chain keto acid dehydrogenase E1, beta Bckdhb <0.001 -0.937
  Glutamic-oxaloacetic transaminase 2, mitochondrial Got2 0.001 -0.819
  Aminoadipate aminotransferase Aadat 0.008 -0.812
  Indoleamine 2,3-dioxygenase 2 Indol1 0.003 -0.810
  Yippee-like 5 Ypel5 <0.001 -0.670
  3-hydroxyisobutyryl-Coenzyme A hydrolase Hibch 0.004 -0.657
Cholesterol metabolic process (GO:0008203) Cytochrome P450, family 7, subfamily a, polypeptide 1 Cyp7a1 0.001 -2.838
  Farnesyl diphosphate synthase) Fdps <0.001 -1.204
  Acetyl-Coenzyme A acetyltransferase 2 Acat2 0.001 -1.166
  Cytochrome P450, family 27, subfamily A, polypeptide 1 Cyp27a1 0.001 -1.082
  Paraoxonase 1 Pon1 0.005 -0.708
  7-dehydrocholesterol reductase Dhcr7 0.001 -0.658
  Emopamil binding protein ( Ebp 0.020 -0.463
Cellular respiration (GO:0045333) Cytochrome c, somatic Cycs 0.002 -1.139
  Mitochondrial ribosomal protein S35 Mrps35 0.004 -0.859
  Coenzyme Q5 homolog, methyltransferase Coq5 0.001 -0.783
  NADH dehydrogenase (ubiquinone) Fe-S protein 1 Ndufs1 0.003 -0.640
  Aconitase 1 Aco1 0.001 -0.627
  Succinate dehydrogenase complex, subunit C Sdhc 0.004 -0.617
  Pyruvate dehydrogenase (lipoamide) beta Pdhb 0.008 -0.558
  1. Symbols of genes changed in both liver and muscle are in bold.