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Table 4 Genes in significant Gene Ontology categories of the biological processes

From: Modulation of gene expression in heart and liver of hibernating black bears (Ursus americanus)

GO category

Gene Name

Gene

Symbol

P value

Fold Change

(Log2FC)

HEART

    

Up-regulated

   

Translation (GO:0006412)

RNA binding motif protein 3

Rbm3

<0.001

2.863

 

Ribosomal protein L35A

Rpl35a

<0.001

1.857

 

Ribosomal protein S23

Rps23

0.001

1.793

 

Ribosomal protein L7A

Rpl7a

0.002

1.287

 

Ribosomal protein L7

Rpl7

<0.001

1.243

 

Eukaryotic translation elongation factor 1 beta 2

Eef1b2

0.001

1.187

 

Ribosomal protein S3

Rps3

0.005

1.166

 

Ribosomal protein L10A

Rpl10a

0.003

1.156

 

Eukaryotic translation initiation factor 5A

Eif5a

<0.001

1.147

 

Ribosomal protein S15A

Rps15a

0.008

1.116

 

Ribosomal protein L27

Rpl27

0.003

1.099

 

Lysyl-trna synthetase

Kars

<0.001

1.075

 

Ribosomal protein S4, X-linked

Rps4x

0.001

1.018

 

Ribosomal protein S13

Rps13

0.003

1.012

 

Ribosomal protein L30

Rpl30

0.002

1.010

 

Ribosomal protein S24

Rps24

0.002

1.000

 

Ribosomal protein, large, P0

Rplp0

0.001

0.936

 

Ribosomal protein L27A

Rpl27a

0.008

0.927

 

Ribosomal protein L22

Rpl22

0.004

0.923

 

Ribosomal protein L36A-like

Rpl36al

0.005

0.917

 

Ubiquitin A-52 residue ribosomal protein fusion product 1

Uba52

0.009

0.915

 

Eukaryotic translation initiation factor 3, subunit G

Eif3g

0.001

0.910

 

Ribosomal protein L5

Rpl5

0.002

0.900

 

Eukaryotic translation initiation factor 3, subunit F

Eif3f

0.003

0.884

 

Ribosomal protein L10A

Rpl10

0.008

0.863

 

Alanyl-trna synthetase domain containing 1

Aarsd1

0.006

0.838

 

Ribosomal protein, large, P2

Rplp2

0.001

0.732

 

Ribosomal protein L24

Rpl24

0.003

0.725

 

Ribosomal protein S27

Rps27

0.001

0.720

 

Eukaryotic translation initiation factor 2, subunit 3 gamma

Eif2s3

0.004

0.668

 

Density-regulated protein

Denr

0.007

0.651

 

Ribosomal protein L18A

Rpl18a

0.002

0.607

LIVER

    

Up-regulated

   

Fatty acid beta-oxidation (GO:0006635)

Acyl-Coenzyme A dehydrogenase, short/branched chain

Acadsb

0.010

0.922

 

Acyl-Coenzyme A dehydrogenase, very long chain

Acadvl

0.001

0.842

 

Hydroxyacyl-Coenzyme A dehydrogenase, beta subunit

Hadhb

0.008

0.711

 

Hydroxyacyl-Coenzyme A dehydrogenase, alpha subunit

Hadha

0.007

0.586

 

Acyl-Coenzyme A dehydrogenase, C-4 to C-12 straight chain

Acadm

0.001

0.510

Translation (GO:0006412)

Ribosomal protein L36

Rpl36

0.004

1.223

 

Ribosomal protein L23

Rpl23

0.003

1.002

 

Nascent polypeptide-associated complex alpha subunit

Naca

0.001

1.182

 

Eukaryotic translation elongation factor 1 delta

Eef1d

0.001

1.170

 

Translocated promoter region (to activated MET oncogene)

Tpr

<0.001

1.116

 

Ribosomal protein S6

Rps6

0.010

1.079

 

Ribosomal protein S20

Rps20

0.002

0.990

 

Ribosomal protein L34

Rpl34

<0.001

0.929

 

Ribosomal protein L9

Rpl9

0.005

0.829

 

Ribosomal protein S16

Rps16

0.001

0.808

 

Mediator complex subunit 8

Med8

0.004

0.683

 

Ribosomal protein L28

Rpl28

0.001

0.617

 

Protein kinase C, alpha

Prkca

0.004

0.572

 

Isoleucyl-trna synthetase

Iars

0.007

0.565

Down-regulated

   

Amino acid catabolic process (GO:0009063)

Arginase, liver

Arg1

0.009

-2.050

 

Glutamic-oxaloacetic transaminase 1, soluble

Got1

0.003

-1.287

 

Coenzyme A carboxylase, beta polypeptide

Pccb

<0.001

-1.176

 

Aldehyde dehydrogenase 6 family, member A1

Aldh6a1

0.006

-1.086

 

Methylcrotonoyl-Coenzyme A carboxylase 2 (beta)

Mccc2

0.001

-1.052

 

Leucine aminopeptidase 3

Lap3

0.008

-0.943

 

Branched chain keto acid dehydrogenase E1, beta

Bckdhb

<0.001

-0.937

 

Glutamic-oxaloacetic transaminase 2, mitochondrial

Got2

0.001

-0.819

 

Aminoadipate aminotransferase

Aadat

0.008

-0.812

 

Indoleamine 2,3-dioxygenase 2

Indol1

0.003

-0.810

 

Yippee-like 5

Ypel5

<0.001

-0.670

 

3-hydroxyisobutyryl-Coenzyme A hydrolase

Hibch

0.004

-0.657

Cholesterol metabolic process (GO:0008203)

Cytochrome P450, family 7, subfamily a, polypeptide 1

Cyp7a1

0.001

-2.838

 

Farnesyl diphosphate synthase)

Fdps

<0.001

-1.204

 

Acetyl-Coenzyme A acetyltransferase 2

Acat2

0.001

-1.166

 

Cytochrome P450, family 27, subfamily A, polypeptide 1

Cyp27a1

0.001

-1.082

 

Paraoxonase 1

Pon1

0.005

-0.708

 

7-dehydrocholesterol reductase

Dhcr7

0.001

-0.658

 

Emopamil binding protein (

Ebp

0.020

-0.463

Cellular respiration (GO:0045333)

Cytochrome c, somatic

Cycs

0.002

-1.139

 

Mitochondrial ribosomal protein S35

Mrps35

0.004

-0.859

 

Coenzyme Q5 homolog, methyltransferase

Coq5

0.001

-0.783

 

NADH dehydrogenase (ubiquinone) Fe-S protein 1

Ndufs1

0.003

-0.640

 

Aconitase 1

Aco1

0.001

-0.627

 

Succinate dehydrogenase complex, subunit C

Sdhc

0.004

-0.617

 

Pyruvate dehydrogenase (lipoamide) beta

Pdhb

0.008

-0.558

  1. Symbols of genes changed in both liver and muscle are in bold.