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Table 1 Common genes among the three experimental groups supplemented with CLA.

From: Gene expression profiles in rat mesenteric lymph nodes upon supplementation with Conjugated Linoleic Acid during gestation and suckling

Gene Symbol

Description

Gene Ontology Biological Process

Ratio A

Ratio B

Ratio C

Actg2

actin, gamma 2, smooth muscle, enteric

 

70.79 D

97.48 D

105.85 D

Cnn1

calponin 1, basic, smooth muscle

actin cytoskeleton organization

17.18 D

20.13 D

19.90 D

Myh11

myosin, heavy chain 11, smooth muscle

smooth muscle contraction

16.49 D

16.57 D

19.68 D

Pcp4

Purkinje cell protein 4

 

12.37 D

12.81 D

12.94 D

Tpm2

tropomyosin 2

regulation of ATPase activity

7.89 D

7.26 D

6.84 D

Krt19

keratin 19

response to estrogen stimulus

7.78 D

5.59 D

9.12 D

Tpm1

Tropomyosin 1, alpha

muscle contraction

7.38 D

8.09 D

8.27 D

Cfb

complement factor B

complement activation

7.11 D

4.99 D

7.82 D

Acta1

actin, alpha 1, skeletal muscle

cell growth

7.10 D

7.54 D

7.18 D

Gal

galanin prepropeptide

inflammatory response

6.38 D

7.03 D

7.72 D

Rnase4

ribonuclease, RNase A family 4

proton transport

5.38 D

2.53 D

4.06 D

Upk1b

uroplakin 1B

epithelial cell differentiation

5.36 D

4.17 D

5.51 D

Rnase4

ribonuclease, RNase A family 4

proton transport

5.36 D

2.38 D

3.58 D

Mylk

myosin light chain kinase

 

5.04 D

4.11 D

3.23 D

Tpm1

tropomyosin 1, alpha

muscle contraction

4.97 D

5.34 D

5.80 D

Tnfaip6

tumor necrosis factor alpha induced 6

cell adhesion

4.94 D

3.35 D

4.39 D

Klhl23

kelch-like 23

 

4.62 D

2.99 D

2.93 D

Tnfrsf11b

tumor necrosis factor receptor 11b

signal transduction

4.37 D

2.02 D

2.46 D

Fhl1

four and a half LIM domains 1

cell differentiation

4.22 D

2.56 D

2.73 D

Synm

synemin, intermediate filament protein

 

3.96 D

3.69 D

4.74 D

Tmem100

transmembrane protein 100

 

3.76 D

3.06 D

3.71 D

Smoc2

SPARC related modular calcium binding 2

cell-substrate adhesion

3.68 D

5.14 D

7.01 D

Pln

phospholamban

calcium ion transport

3.68 D

3.66 D

3.89 D

Tm4sf1

transmembrane 4 L six family member 1

 

3.61 D

2.09 D

2.35 D

Acin1

apoptotic chromatin condensation inducer 1

chromosome condensation

3.59 U

3.09 U

2.69 U

Grem2

gremlin 2, cysteine knot superfamily, homolog

BMP signaling pathway

3.52 D

3.38 D

4.83 D

Pik3c2b

phosphoinositide-3-kinase, class 2, beta

cell communication

3.45 U

3.42 U

2.95 U

Fbxl22

F-box and leucine-rich repeat protein 22

 

3.36 D

3.72 D

3.67 D

Nupr1

nuclear protein 1

acute inflammatory response

3.31 D

3.00 D

3.01 D

Nov

nephroblastoma overexpressed gene

regulation of cell growth

3.27 D

3.10 D

3.48 D

Scg2

secretogranin II

MAPKKK cascade

3.22 D

3.16 D

3.15 D

Rbm5

RNA binding motif protein 5

nuclear mRNA splicing

3.14 U

3.99 U

4.04 U

Tpm1

tropomyosin 1, alpha

muscle contraction

3.11 D

3.29 D

3.27 D

Tpm1

tropomyosin 1, alpha

muscle contraction

3.11 D

4.63 D

4.57 D

Bzrap1

benzodiazapine receptor associated protein 1

 

3.08 U

3.61 U

3.25 U

Zeb2

Zinc finger E-box binding homeobox 2

regulation of transcription

3.07 U

5.80 U

2.06 U

Adamts1

ADAM metallopeptidase with thrombospondin 1

proteolysis

3.01 D

2.26 D

2.34 D

Myl9

myosin, light chain 9, regulatory

 

3.01 D

5.94 D

5.54 D

Gap43

growth associated protein 43

regulation of cell growth

2.98 D

3.34 D

3.22 D

Aldh1a1

aldehyde dehydrogenase 1 family, A1

metabolic process

2.94 D

2.77 D

2.91 D

Krt8

keratin 8

apoptosis

2.93 D

3.97 D

3.54 D

Gstm5

glutathione S-transferase, mu 5

metabolic process

2.86 D

3.14 D

2.81 D

Sh3bgr

SH3 domain binding glutamic acid-rich

 

2.85 D

3.32 D

3.40 D

Prph

peripherin

cytoskeleton organization

2.81 D

3.59 D

4.12 D

Ctgf

connective tissue growth factor

cartilage condensation

2.80 D

3.59 D

5.12 D

Sparcl1

SPARC-like 1

 

2.74 D

2.00 D

2.65 D

Pgm5

phosphoglucomutase 5

carbohydrate metabolism

2.74 D

3.86 D

4.72 D

Klhl23

kelch-like 23

 

2.74 D

2.26 D

2.16 D

Fhl1

four and a half LIM domains 1

cell differentiation

2.73 D

2.74 D

3.13 D

Acta2

smooth muscle alpha-actin

muscle contraction

2.70 D

4.63 D

2.86 D

Msln

mesothelin

cell adhesion

2.69 D

2.58 D

3.63 D

Sstr3

somatostatin receptor 3

signal transduction

2.67 U

3.11 U

2.90 U

Ppp1r14a

protein phosphatase 1, regulatory subunit 14A

phosphorylation

2.65 D

4.99 D

4.83 D

Timp1

TIMP metallopeptidase inhibitor 1

cell activation

2.64 D

4.04 D

4.54 D

Bcl2l2//Pabpn1

Bcl2-like 2//poly(A) binding protein nuclear 1

apoptosis

2.64 U

2.40 U

2.40 U

Ash1l

Ash1 (absent, small, or homeotic)-like

 

2.58 U

3.43 U

3.85 U

Mylk

myosin light chain kinase

 

2.57 D

3.10 D

3.94 D

Adh1

alcohol dehydrogenase 1

retinoid metabolism

2.52 D

2.52 D

2.56 D

Ptgis

prostaglandin I2 synthase

prostaglandin biosynthesis

2.48 D

2.92 D

3.33 D

Stmn2

stathmin-like 2

intracellular signaling

2.45 D

2.40 D

2.33 D

Gpd1

glycerol-3-phosphate dehydrogenase 1

gluconeogenesis

2.43 D

2.40 D

2.79 D

Pdlim3

PDZ and LIM domain 3

actin filament organization

2.42 D

2.33 D

2.50 D

Cgnl1

cingulin-like 1

 

2.41 D

2.01 D

2.15 D

Pla2g2a

phospholipase A2, group IIA

phospholipid metabolism

2.41 D

2.93 D

3.05 D

Ikzf2

IKAROS family zinc finger 2

 

2.39 U

5.10 U

4.82 U

Rgs4

regulator of G-protein signaling 4

signal transduction

2.39 D

2.27 D

2.55 D

Argbp2

Arg/Abl-interacting protein ArgBP2

intracellular signaling

2.36 D

2.30 D

2.45 D

Fgf13

fibroblast growth factor 13

MAPKKK cascade

2.35 D

2.80 D

2.86 D

Igf2

insulin-like growth factor 2

cell proliferation

2.30 D

4.82 D

6.01 D

Syt1

synaptotagmin I

transport

2.29 D

2.46 D

2.30 D

Hspb1

heat shock protein 1

response to heat

2.24 D

3.69 D

5.15 D

Gja5

gap junction protein, alpha 5

cell communication

2.24 D

3.04 D

2.93 D

Schip1

schwannomin interacting protein 1

 

2.23 D

2.92 D

2.80 D

Efemp1

EGF-containing fibulin-like extracellular matrix 1

 

2.23 D

2.41 D

3.39 D

Cxcr7

chemokine (C-X-C motif) receptor 7

signal transduction

2.22 D

2.24 D

3.13 D

Phemx

pan hematopoietic expression

 

2.21 U

2.56 U

2.61 U

Gpc3

glypican 3

regulation of growth

2.20 D

3.02 D

4.39 D

Leng8

leukocyte receptor cluster member 8

 

2.20 U

2.34 U

2.10 U

Crispld2

cysteine-rich secretory protein LCCL domain containing 2

lung development

2.20 D

3.82 D

3.77 D

Tagln

transgelin

cytoskeleton organization

2.20 D

3.49 D

3.54 D

Grb2

growth factor receptor bound protein 2

MAPKKK cascade

2.19 U

2.42 U

2.25 U

Parva

parvin, alpha

cell adhesion

2.16 D

2.04 D

2.30 D

Hist1h4b

histone cluster 1, H4b

nucleosome assembly

2.15 U

2.44 U

2.08 U

Des

desmin

 

2.12 D

3.69 D

4.05 D

Cryab

crystallin, alpha B

glucose metabolic process

2.09 D

3.37 D

3.18 D

Enpp3

ectonucleotidepyrophosphatase phosphodiesterase 3

phosphate metabolism

2.05 D

2.21 D

2.52 D

Bag2

Bcl2-associated athanogene 2

apoptosis

2.04 D

3.04 D

3.12 D

Wfdc1

WAP four-disulfide core domain 1

regulation of cell growth

2.01 D

2.66 D

2.80 D

Cd9

CD9 molecule

cell adhesion

2.01 D

2.24 D

2.12 D

  1. The lists of genes differentially expressed by 2-fold with a p-value < 0.05 obtained for each experimental group were compared using Venn Diagrams in GeneSpring GX software v 10.0.2. The table shows the list of genes differentially expressed in all three conditions, and includes the Gene Symbol for all genes, their associated description and one of the Gene Onthology categories to which the genes belong according to GeneSpring GX. The ratio columns correspond to the absolute fold change in expression for the genes in each experimental group (A, B or C) relative to the control group (D) and the type of regulation (U, upregulation; D, downregulation)