Figure 5

Cross-species comparison of TCDD-elicited gene expression responses at 24 hrs using 4 × 44 k Agilent microarrays. (A) The lower half (dark boxes) of the matrix show the number or orthologous genes represented between pairs of species-specific microarrays. The upper half (grey boxes) provides the number of TCDD-elicited differentially expressed orthologs between pairs of cell lines. (B) The 3-way Venn diagram shows the overlap of all differentially expressed genes (P1(t) > 0.999 and |fold change| > 1.4) from 12,388 possible orthologous genes represented across all three platforms. The 9 genes differentially expressed in all three cell lines are listed in Table 3. Additional files 16, 17, 18 lists the shared responses between pairs of species.