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Table 6 Functional enrichment analysis of differentially regulateda genes elicited by TCDD in H4IIE cells using DAVID.

From: Differences in TCDD-elicited gene expression profiles in human HepG2, mouse Hepa1c1c7 and rat H4IIE hepatoma cells

Category

Term

Gene count

Fold enrichment

P-value

Enrichment Score: 3.05

   

   GOTERM_BP_3

GO:0006805 ~ xenobiotic metabolic process

7

34.21

3.52E-08

   GOTERM_BP_3

GO:0009410 ~ response to xenobiotic stimulus

7

31.47

6.09E-08

   GOTERM_BP_3

GO:0006725 ~ cellular aromatic compound metabolic process

6

5.07

6.28E-03

   GOTERM_BP_3

GO:0017144 ~ drug metabolic process

3

16.86

1.31E-02

   GOTERM_BP_3

GO:0051186 ~ cofactor metabolic process

6

3.61

2.44E-02

   GOTERM_BP_3

GO:0046483 ~ heterocycle metabolic process

5

1.78

3.03E-01

   GOTERM_BP_3

GO:0044248 ~ cellular catabolic process

8

1.39

3.41E-01

Enrichment Score: 2.45

   

   GOTERM_BP_3

GO:0010035 ~ response to inorganic substance

11

4.70

1.00E-04

   GOTERM_BP_3

GO:0006800 ~ oxygen and reactive oxygen species metabolic process

5

10.81

1.10E-03

   GOTERM_BP_3

GO:0006979 ~ response to oxidative stress

7

4.50

4.38E-03

   GOTERM_BP_3

GO:0044248 ~ cellular catabolic process

8

1.39

3.41E-01

Enrichment Score: 1.59

   

   GOTERM_BP_3

GO:0006629 ~ lipid metabolic process

14

2.49

3.37E-03

   GOTERM_BP_3

GO:0006082 ~ organic acid metabolic process

12

2.71

4.12E-03

   GOTERM_BP_3

GO:0042180 ~ cellular ketone metabolic process

12

2.68

4.57E-03

   GOTERM_BP_3

GO:0044255 ~ cellular lipid metabolic process

11

2.77

5.68E-03

   GOTERM_BP_3

GO:0005996 ~ monosaccharide metabolic process

7

4.23

5.88E-03

   GOTERM_BP_3

GO:0016051 ~ carbohydrate biosynthetic process

5

6.18

8.38E-03

   GOTERM_BP_3

GO:0044262 ~ cellular carbohydrate metabolic process

7

2.63

4.80E-02

   GOTERM_BP_3

GO:0046165 ~ alcohol biosynthetic process

3

8.03

5.25E-02

   GOTERM_BP_3

GO:0005975 ~ carbohydrate metabolic process

8

2.25

6.22E-02

   GOTERM_BP_3

GO:0006091 ~ generation of precursor metabolites and energy

5

2.70

1.11E-01

   GOTERM_BP_3

GO:0008610 ~ lipid biosynthetic process

4

1.71

4.09E-01

   GOTERM_BP_3

GO:0044249 ~ cellular biosynthetic process

16

1.04

5.74E-01

Enrichment Score: 1.58

   

   GOTERM_BP_3

GO:0042493 ~ response to drug

11

3.94

4.20E-04

   GOTERM_BP_3

GO:0006869 ~ lipid transport

4

3.91

8.07E-02

   GOTERM_BP_3

GO:0010876 ~ lipid localization

4

3.54

1.01E-01

   GOTERM_BP_3

GO:0042592 ~ homeostatic process

10

1.66

1.39E-01

Enrichment Score: 1.54

   

   GOTERM_BP_3

GO:0044255 ~ cellular lipid metabolic process

11

2.77

5.68E-03

   GOTERM_BP_3

GO:0006721 ~ terpenoid metabolic process

3

10.54

3.20E-02

   GOTERM_BP_3

GO:0006766 ~ vitamin metabolic process

3

4.75

1.29E-01

  1. aDifferentially regulated genes with P1(t) > 0.999 and |foldchange| > 1.4
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BMC Genomics

ISSN: 1471-2164

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