Table 1 List of gene set regulated by NGF in HMC-1 (V560G c-Kit) cells.

CYTOKINES

CLCF1

NM_013246

cardiotrophin-like cytokine factor 1

2.6

FASLG

NM_000639

Fas ligand (TNF superfamily, member 6)

3.0

IL1B

NM_000576

interleukin 1, beta

2.2

LIF

NM_002309

leukemia inhibitory factor (cholinergic differentiation factor)

2.4

LTB

NM_002341

lymphotoxin beta (TNF superfamily, member 3)

2.2

GROWTH FACTOR

GDF15

NM_004864

growth differentiation factor 15

3.2

ENZYMES

ARL5B

NM_178815

ADP-ribosylation factor-like 5B

3.1

B3GALNT2

NM_152490

beta-1,3-N-acetylgalactosaminyltransferase 2

2.8

CYCS

NM_018947

cytochrome c, somatic

2.6

GALNT4

NM_003774

UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 4 (GalNAc-T4)

3.2

GEM

NM_005261

GTP binding protein overexpressed in skeletal muscle

2.9

LFNG

NM_001040167

LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase

2.5

PAICS

NM_006452

phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase

2.9

RRAD

NM_004165

Ras-related associated with diabetes

2.5

TEP1

NM_007110

telomerase-associated protein 1

3.8

UBE2E1

NM_152653

ubiquitin-conjugating enzyme E2E 1 (UBC4/5 homolog, yeast)

4.2

KINASES

AATK

AK131529

cDNA FLJ16758 fis, clone BRACE3038687, moderately similar to Homo sapiens apoptosis-associated tyrosine kinase (AATK)

2.5

PANK2

AL713654

Homo sapiens mRNA; cDNA DKFZp547J0513 (from clone DKFZp547J0513).

2.2

PLK3

NM_004073

polo-like kinase 3 (Drosophila)

5.1

PRKAR2A

NM_004157

protein kinase, cAMP-dependent, regulatory, type II, alpha

3.4

SGK1

NM_005627

serum/glucocorticoid regulated kinase

2.3

TRIB1

NM_025195

tribbles homolog 1 (Drosophila)

2.8

LIGAND DEPENDENT NUCLEAR RECEPTOR

NR4A1

NM_002135

nuclear receptor subfamily 4, group A, member 1

4.7

NR4A2

NM_006186

nuclear receptor subfamily 4, group A, member 2

2.8

NR4A3

NM_006981

nuclear receptor subfamily 4, group A, member 3

2.6

G-PROTEIN COUPLED RECEPTORS

CXCR4

NM_001008540

chemokine (C-X-C motif) receptor 4 (CXCR4), transcript variant 1

2.0

HRH1

NM_000861

histamine receptor H1

2.1

PEPTIDASE

CTSZ

NM_001336

cathepsin Z

3.0

TRANSCRIPTON REGULATOR

ACTN2

NM_001103

actinin, alpha 2

2.5

ARNTL2

NM_020183

aryl hydrocarbon receptor nuclear translocator-like 2

2.2

ATF3

NM_004024

Homo sapiens activating transcription factor 3 (ATF3), transcript variant 2

2.9

AXUD1

NM_033027

AXIN1 up-regulated 1 (AXUD1)

2.5

EGR1

NM_001964

early growth response 1

29.6

EGR2

NM_000399

early growth response 2

13.6

EGR3

NM_004430

early growth response 3

22.8

EGR4

NM_001965

early growth response 4

5.2

ETV5

NM_004454

ets variant 5

3.2

FOS

NM_005252

FBJ murine osteosarcoma viral oncogene homolog

3.5

FOSB

NM_006732

Homo sapiens FBJ murine osteosarcoma viral oncogene homolog B (FOSB)

3.7

FOSL1

NM_005438

FOS-like antigen 1

4.7

FOSL2

NM_005253

FOS-like antigen 2

2.5

HES1

NM_005524

hairy and enhancer of split 1, (Drosophila)

3.4

HOXB8

NM_024016

homeobox B8

14.1

JUNB

NM_002229

jun B proto-oncogene

2.1

KLF10

NM_005655

Kruppel-like factor 10 (KLF10), transcript variant 1

7.5

KLF2

NM_016270

Kruppel-like factor 2 (lung)

2.9

MAFF

NM_012323

v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian) (MAFF), transcript variant 1

2.6

MYC

NM_002467

v-myc myelocytomatosis viral oncogene homolog (avian)

4.1

NAB2

NM_005967

NGFI-A binding protein 2 (EGR1 binding protein 2)

2.2

NOC2L

NM_015658

nucleolar complex associated 2 homolog (S. cerevisiae)

2.6

PBX2

NM_002586

pre-B-cell leukemia homeobox 2

2.7

POLR3E

AB040885

mRNA for KIAA1452 protein, partial cds.

4.0

RYBP

NM_012234

RING1 and YY1 binding protein

2.3

SF1

NM_004630

splicing factor 1

6.4

SKIL

NM_005414

SKI-like (SKIL)

3.1

SMAD7

NM_005904

SMAD family member 7

2.2

ST18

NM_014682

suppression of tumorigenicity 18 (breast carcinoma) (zinc finger protein)

2.0

ZFP36

NM_003407

zinc finger protein 36, C3H type, homolog (mouse)

2.3

ZFP36L1

NM_004928

zinc finger protein 36, C3H type-like 1

2.6

TRANSPORTERS

AP1S1

NM_057089

adaptor-related protein complex 1, sigma 1 subunit (AP1S1), transcript variant 2

2.3

APOL6

NM_030641

apolipoprotein L, 6

3.9

GGA1

NM_001001560

golgi-associated, gamma adaptin ear containing, ARF binding protein 1

3.1

MCL1

NM_021960

myeloid cell leukemia sequence 1 (BCL2-related)

2.3

SLC2A14

BC060766

solute carrier family 2 (facilitated glucose transporter), member 14, mRNA (cDNA clone MGC:71510 IMAGE:5297510), complete cds. [BC060766]

2.9

SLC2A3

NM_006931

solute carrier family 2 (facilitated glucose transporter), member 3

2.5

STX1A

NM_004603

syntaxin 1A (brain) (STX1A)

2.5

TMC6

NM_152453

transmembrane and coiled-coil domains 5 (TMCO5)

3.3

PHOSPHATASES

DUSP4

NM_001394

dual specificity phosphatase 4

2.7

DUSP5

NM_004419

dual specificity phosphatase 5

2.1

DUSP6

NM_001946

dual specificity phosphatase 6

19.9

EYA4

NM_004100

eyes absent homolog 4 (Drosophila)

2.1

OTHERS

ADM

NM_001124

adrenomedullin

2.4

CASC5

NM_170589

cancer susceptibility candidate 5 (CASC5), transcript variant 1

3.3

CCDC71

NM_022903

coiled-coil domain containing 71

3.1

CCND1

NM_053056

cyclin D1

8.3

CDKN1A

NM_000389

cyclin-dependent kinase inhibitor 1A (p21, Cip1)

2.5

CLN8

NM_018941

ceroid-lipofuscinosis, neuronal 8 (epilepsy, progressive with mental retardation)

2.2

PSCD4

NM_013385

pleckstrin homology, Sec7 and coiled-coil domains 4 (PSCD4),

3.4

DDIT4

NM_019058

Homo sapiens DNA-damage-inducible transcript 4 (DDIT4),

2.4

FAM40B

NM_020704

family with sequence similarity 40, member B (FAM40B)

4.4

FBXL17

BC018548

F-box and leucine-rich repeat protein 17, mRNA (cDNA clone IMAGE:4215262), partial cds. [BC018548]

5.1

FST

NM_013409

follistatin

2.2

GNL3L

NM_019067

guanine nucleotide binding protein-like 3 (nucleolar)-like

2.3

GOLGA1

NM_002077

golgin A1

3.7

HNRNPA0

NM_006805

heterogeneous nuclear ribonucleoprotein A0 (HNRPA0)

3.0

IER2

NM_004907

immediate early response 2

2.5

IER3

NM_003897

immediate early response 3

9.2

LMNB1

NM_005573

lamin B1

3.0

LRRC8B

NM_015350

leucine rich repeat containing 8 family, member B (LRRC8B)

2.0

LUZP1

NM_033631

leucine zipper protein 1 (LUZP1)

2.8

MALAT1

NR_002819

metastasis associated lung adenocarcinoma transcript 1 (non-protein coding)

4.9

MED18

NM_017638

mediator of RNA polymerase II transcription, subunit 18 homolog (S. cerevisiae) (MED18)

15.0

METTL7A

NM_014033

methyltransferase like 7A

2.6

MYEOV

NM_138768

myeloma overexpressed (in a subset of t(11;14) positive multiple myelomas)

3.7

NUP188

BC005407

nucleoporin 188kDa, mRNA (cDNA clone IMAGE:3461492), partial cds. [BC005407]

2.8

PER2

NM_022817

period homolog 2 (Drosophila)

2.5

PHLDA1

NM_007350

pleckstrin homology-like domain, family A, member 1

9.7

PHLDA2

NM_003311

pleckstrin homology-like domain, family A, member 2

2.3

PMAIP1

NM_021127

phorbol-12-myristate-13-acetate-induced protein 1

3.6

PRNP

NM_000311

prion protein

3.2

RAPGEF5

D87467

mRNA for KIAA0277 gene, partial cds. [D87467]

18.5

RNF125

NM_017831

ring finger protein 125

5.1

RPL23

BC034378

ribosomal protein L23, mRNA (cDNA clone MGC:34067 IMAGE:5186030), complete cds. [BC034378]

2.3

SERPINE1

NM_000602

serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1

3.3

SH2B3

NM_005475

SH2B adaptor protein 3

2.4

SH2D2A

NM_003975

SH2 domain protein 2A (SH2D2A)

2.1

SPRED1

NM_152594

sprouty-related, EVH1 domain containing 1

6.4

SPRED2

NM_181784

sprouty-related, EVH1 domain containing 2

3.1

SPRY2

NM_005842

sprouty homolog 2 (Drosophila)

6.6

TMEM49

NM_030938

transmembrane protein 49

7.3

TMEPAI

NM_020182

transmembrane, prostate androgen induced RNA (TMEPAI), transcript variant 1

4.2

TNFRSF12A

NM_016639

tumor necrosis factor receptor superfamily, member 12A

4.8

UBQLN1

NM_013438

ubiquilin 1

4.6

ZC3H7B

NM_017590

zinc finger CCCH-type containing 7B

3.9

ZCCHC2

NM_017742

zinc finger, CCHC domain containing 2

2.2

ZNF295

NM_020727

zinc finger protein 295 (ZNF295)

2.8

VIL2

NM_003379

villin 2 (ezrin) (VIL2)

2.3