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Table 1 Classification of significantly expressed genes in tissues of 9 V/null and 4L mice

From: Global gene expression profile progression in Gaucher disease mouse models

Categories

Lung

Liver

 

9 V/null

4L

9 V/null

4L

 

No.

%

p-value

No.

%

p-value

No.

%

p-value

No.

%

p-value

catalytic activity

440

38%

1.49E-06

527

39%

4.24E-09

160

40%

3.37E-04

157

39%

2.61E-03

intracellular signaling cascade

136

12%

7.49E-10

166

12%

2.40E-10

50

13%

7.50E-04

46

11%

1.24E-03

kinase activity

87

8%

8.41E-04

98

7%

1.41E-03

34

9%

8.07E-03

31

7%

4.46E-02

lipid metabolic process

66

6%

7.62E-04

73

5%

1.43E-02

37

9%

1.22E-05

30

7%

7.71E-04

macrophage activation

119

10%

4.50E-04

83

6%

3.29E-03

24

6%

5.74E-03

26

6%

6.93E-03

transcription

195

17%

1.44E-03

276

20%

2.33E-08

83

21%

2.50E-03

76

19%

4.17E-03

cell death

75

7%

1.36E-04

89

7%

3.83E-04

27

7%

4.93E-02

   

cytoskeleton

78

7%

3.92E-02

87

7%

5.96E-03

      

lysosome

29

3%

1.91E-05

27

2%

1.43E-03

      

response to stress

79

7%

1.52E-03

91

7%

1.20E-02

      

transport

219

19%

2.14E-04

255

19%

8.03E-03

      

immune response

54

5%

4.68E-03

         
  1. The functional categories with p-value < 0.05 were considered significant by Fisher Exact Test.
  2. No. = number of genes
  3. The empty rows were not significant (p > 0.05)