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Table 2 Expression of pro- and anti-inflammatory macrophage activation genes in lungs of 9 V/null and 4L mice

From: Global gene expression profile progression in Gaucher disease mouse models

    9 V/null 4L
Pathways Symbol Gene Name lu_4 wk lu_12 wk lu_18 wk lu_28 wk lu_4 wk lu_12 wk lu_18 wk lu_28 wk
IFNγ regulated IFNγ* interferon gamma 1.124 1.292 1.336 1.204 1.513 1.278 1.329 1.435
  CCL19 chemokine (C-C motif) ligand 19 1.325 3.288 3.336 2.039 1.738 1.469 1.166 1.536
  CCL2* chemokine (C-C motif) ligand 2 1.134 2.835 2.564 2.467 1.284 1.220 1.203 1.463
  CCL3* chemokine (C-C motif) ligand 3 1.855 19.86 37.518 22.298 1.464 1.673 1.155 1.347
  CCL6 chemokine (C-C motif) ligand 6 2.004 4.073 6.557 6.138 -1.380 -1.090 -1.344 1.228
  CCL9* chemokine (C-C motif) ligand 9 1.893 5.817 10.346 9.722 1.317 1.546 1.512 1.365
  CD44 CD44 antigen 3.176 4.971 2.155 2.387 1.060 1.156 -1.045 1.294
  CXCL1 chemokine (C-X-C motif) ligand 1 1.466 8.56 10.786 7.739 1.322 1.252 -1.183 1.663
  CXCL12 chemokine (C-X-C motif) ligand 12 2.65 2.991 1.923 1.874 1.679 1.334 1.130 1.030
  IL-6* interleukin 6 -1.249 1.189 1.029 -1.009 -1.080 -1.261 -1.262 -1.106
  Msr1 macrophage scavenger receptor 1 1.092 2.843 2.808 2.322 1.349 1.515 -1.089 1.076
  NOS2* nitric oxide synthase 2, inducible, macrophage 1.226 1.207 -1.001 1.13 1.206 1.351 -1.001 1.200
  TNF* tumor necrosis factor -1.096 1.036 1.279 1.337 1.184 1.384 -1.008 1.451
IL-4 regulated IL-4* interleukin 4 -1.074 -1.007 1.135 1.253 -1.071 1.286 1.107 1.367
  Arg2 arginase type II 1.315 2.661 3.044 2.034 1.787 2.179 1.298 1.344
  CCL17 chemokine (C-C motif) ligand 17 1.146 3.756 8.523 5.903 1.982 2.494 1.522 1.674
  CCL22 chemokine (C-C motif) ligand 22 1.237 3.066 2.734 2.725 1.402 1.477 1.096 1.559
  CD163* CD163 antigen -1.029 1.013 -1.446 -1.391 1.173 1.142 1.234 -1.335
  Igh-6 Immunoglobulin heavy chain 6 3.036 3.066 3.430 2.565 2.864 1.810 1.724 1.637
  IL-1rn interleukin 1 receptor antagonist 1.417 3.615 3.815 2.762 1.296 1.317 1.376 1.141
  MMP12* matrix metallopeptidase 12 1.705 37.346 56.278 39.721 1.225 1.023 -1.240 1.217
  MMP19 matrix metallopeptidase 19 1.762 3.607 3.428 3.112 1.659 1.650 1.563 -1.249
  MMP9 matrix metallopeptidase 9 1.272 2.837 4.307 2.308 -1.353 1.233 1.199 1.226
  Retnlα resistin like alpha 1.920 2.229 2.480 3.800 2.796 1.538 2.536 1.840
  1. Note: The gene symbols in Bold were not significantly expressed in microarray analysis, but were positive on immunohistochemstry in 9 V/null lung. The numbers show Fold Change in gene expression. The numbers in Bold were significantly affected and satisfied with FDR (≤0.01) and Fold Change at ≥ ± 1.8. Genes with * sign were positive on immunohistochemistry. wk = week.