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Table 2 Expression of pro- and anti-inflammatory macrophage activation genes in lungs of 9 V/null and 4L mice

From: Global gene expression profile progression in Gaucher disease mouse models

   

9 V/null

4L

Pathways

Symbol

Gene Name

lu_4 wk

lu_12 wk

lu_18 wk

lu_28 wk

lu_4 wk

lu_12 wk

lu_18 wk

lu_28 wk

IFNγ regulated

IFNγ*

interferon gamma

1.124

1.292

1.336

1.204

1.513

1.278

1.329

1.435

 

CCL19

chemokine (C-C motif) ligand 19

1.325

3.288

3.336

2.039

1.738

1.469

1.166

1.536

 

CCL2*

chemokine (C-C motif) ligand 2

1.134

2.835

2.564

2.467

1.284

1.220

1.203

1.463

 

CCL3*

chemokine (C-C motif) ligand 3

1.855

19.86

37.518

22.298

1.464

1.673

1.155

1.347

 

CCL6

chemokine (C-C motif) ligand 6

2.004

4.073

6.557

6.138

-1.380

-1.090

-1.344

1.228

 

CCL9*

chemokine (C-C motif) ligand 9

1.893

5.817

10.346

9.722

1.317

1.546

1.512

1.365

 

CD44

CD44 antigen

3.176

4.971

2.155

2.387

1.060

1.156

-1.045

1.294

 

CXCL1

chemokine (C-X-C motif) ligand 1

1.466

8.56

10.786

7.739

1.322

1.252

-1.183

1.663

 

CXCL12

chemokine (C-X-C motif) ligand 12

2.65

2.991

1.923

1.874

1.679

1.334

1.130

1.030

 

IL-6*

interleukin 6

-1.249

1.189

1.029

-1.009

-1.080

-1.261

-1.262

-1.106

 

Msr1

macrophage scavenger receptor 1

1.092

2.843

2.808

2.322

1.349

1.515

-1.089

1.076

 

NOS2*

nitric oxide synthase 2, inducible, macrophage

1.226

1.207

-1.001

1.13

1.206

1.351

-1.001

1.200

 

TNF*

tumor necrosis factor

-1.096

1.036

1.279

1.337

1.184

1.384

-1.008

1.451

IL-4 regulated

IL-4*

interleukin 4

-1.074

-1.007

1.135

1.253

-1.071

1.286

1.107

1.367

 

Arg2

arginase type II

1.315

2.661

3.044

2.034

1.787

2.179

1.298

1.344

 

CCL17

chemokine (C-C motif) ligand 17

1.146

3.756

8.523

5.903

1.982

2.494

1.522

1.674

 

CCL22

chemokine (C-C motif) ligand 22

1.237

3.066

2.734

2.725

1.402

1.477

1.096

1.559

 

CD163*

CD163 antigen

-1.029

1.013

-1.446

-1.391

1.173

1.142

1.234

-1.335

 

Igh-6

Immunoglobulin heavy chain 6

3.036

3.066

3.430

2.565

2.864

1.810

1.724

1.637

 

IL-1rn

interleukin 1 receptor antagonist

1.417

3.615

3.815

2.762

1.296

1.317

1.376

1.141

 

MMP12*

matrix metallopeptidase 12

1.705

37.346

56.278

39.721

1.225

1.023

-1.240

1.217

 

MMP19

matrix metallopeptidase 19

1.762

3.607

3.428

3.112

1.659

1.650

1.563

-1.249

 

MMP9

matrix metallopeptidase 9

1.272

2.837

4.307

2.308

-1.353

1.233

1.199

1.226

 

Retnlα

resistin like alpha

1.920

2.229

2.480

3.800

2.796

1.538

2.536

1.840

  1. Note: The gene symbols in Bold were not significantly expressed in microarray analysis, but were positive on immunohistochemstry in 9 V/null lung. The numbers show Fold Change in gene expression. The numbers in Bold were significantly affected and satisfied with FDR (≤0.01) and Fold Change at ≥ ± 1.8. Genes with * sign were positive on immunohistochemistry. wk = week.
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BMC Genomics

ISSN: 1471-2164

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