Figure 3

Schematic representation of key genes found associated with estrous behavior and their relationship with estrus. Some of the key genes whose expressions in the brain areas were found associated with estrous behavior are depicted here along with mechanisms affected during estrus that are important for estrous behavior. GnRH released from the DH stimulates release of FSH and LH from the AP which in turn influences the ovary to release estrogen and progesterone (Hypothalamic-pituitary-gonadal axis). In the brain areas, estrogen influences expression of OXT and AVP, which play major roles in the regulation of sexual behavior. The neurotransmitter receptors, GABRA6, HTR2A and DRD2 affect sexual motivation, whereas CHRM1, CHRM3 and CHRNA5 along with "immune related" genes like CTLA4, IL1RL1 and MARCO affect neuronal plasticity. The genes POMC, MCHR1 and TTR are involved in altering anxiety, stress and feeding motivation.