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Table 5 Genes showing hormonal and genotype transcriptional differences, with co-dependence

From: The testosterone-dependent and independent transcriptional networks in the hypothalamus of Gpr54 and Kiss1 knockout male mice are not fully equivalent

  

Genotype Effect within Hormonal Group

Hormonal Effect within Genotype

 
  

No testosterone

Testosterone

Wild-type

Knockout

 

Genotype

Gene

FC (95%CI)

Dir

FC (95%CI)

Dir

FC (95%CI)

Dir

FC (95%CI)

Dir

p -value

GKO

Acsm3

1.26(1.01-1.57)

Up

2.28(1.84-2.83)

Down

1.93(1.54-2.42)

Up

1.49(1.21-1.84)

Down

2.02E-08

GKO

Ar

1.23(1.09-1.38)

Down

1.56(1.39-1.75)

Down

1.13(1.01-1.27)

Up

1.12(1.00-1.25)

Down

1.02E-08

GKO

Esr1

1.08(0.96-1.21)

Down

1.31(1.17-1.47)

Down

1.28(1.14-1.43)

Down

1.55(1.39-1.74)

Down

1.36E-11

GKO

Gnrhr

1.28(0.78-2.12)

Down

3.20(1.70-6.03)

Up

2.29(1.37-3.82)

Down

1.80(0.96-3.35)

Up

1.80E-03

GKO

Kiss1

1.95(1.58-2.42)

Up

1.09(0.88-1.35)

Up

9.12(7.36-11.29)

Down

16.34(13.19-20.23)

Down

5.71E-52

GKO

Klk1b22

1.25(0.71-2.20)

Up

2.70(1.61-4.52)

Down

1.08(0.61-1.91)

Down

3.65(2.17-6.12)

Down

0.0004

GKO

Mmp9

1.11(0.91-1.35)

Up

1.70(1.40-2.07)

Up

1.11(0.92-1.35)

Up

1.71(1.41-2.08)

Up

2.69E-07

GKO

Six2

1.05(0.73-1.50)

Down

2.22(1.55-3.18)

Up

1.78(1.24-2.55)

Down

1.30(0.91-1.87)

Up

0.0022

GKO

Tec

2.48(1.95-3.14)

Down

1.75(1.38-2.22)

Down

1.63(1.29-2.07)

Down

1.16(0.91-1.46)

Down

2.03E-13

GKO

Txnip

1.04(0.80-1.34)

Down

1.81(1.40-2.35)

Up

1.85(1.43-2.39)

Down

1.02(0.79-1.32)

Up

8.79E-05

KKO

Acsm3

1.23(1.03-1.48)

Up

1.27(1.03-1.56)

Down

1.86(1.53-2.26)

Up

1.19(0.98-1.45)

Up

9.80E-06

KKO

Klk1b22

1.30(0.92-1.84)

Down

4.30(3.01-6.15)

Down

1.34(0.97-1.84)

Down

4.43(3.01-6.51)

Down

1.75E-09

KKO

Mmp9

1.03(0.68-1.56)

Down

3.75(2.44-5.75)

Down

1.08(0.74-1.59)

Down

3.93(2.48-6.22)

Down

0.0127

KKO

Six2

1.08(0.84-1.40)

Up

1.99(1.54-2.57)

Up

1.60(1.24-2.07)

Down

1.15(0.89-1.49)

Up

1.14E-05

KKO

Tec

1.07(0.86-1.32)

Down

1.72(1.39-2.12)

Up

1.63(1.32-2.02)

Down

1.12(0.91-1.38)

Up

1.82E-05

KKO

Txnip

1.16(1.00-1.34)

Down

1.22(1.06-1.41)

Up

1.66(1.44-1.92)

Down

1.18(1.02-1.36)

Down

3.01E-08

  1. FC = fold change, CI = confidence interval, Dir = Direction relative to WT (genotype subpanel) or T (hormone subpanel). GKO = GPR54 knockout, KKO = Kisspeptin knockout.