Skip to main content

Table 5 Genes showing hormonal and genotype transcriptional differences, with co-dependence

From: The testosterone-dependent and independent transcriptional networks in the hypothalamus of Gpr54 and Kiss1 knockout male mice are not fully equivalent

   Genotype Effect within Hormonal Group Hormonal Effect within Genotype  
   No testosterone Testosterone Wild-type Knockout  
Genotype Gene FC (95%CI) Dir FC (95%CI) Dir FC (95%CI) Dir FC (95%CI) Dir p -value
GKO Acsm3 1.26(1.01-1.57) Up 2.28(1.84-2.83) Down 1.93(1.54-2.42) Up 1.49(1.21-1.84) Down 2.02E-08
GKO Ar 1.23(1.09-1.38) Down 1.56(1.39-1.75) Down 1.13(1.01-1.27) Up 1.12(1.00-1.25) Down 1.02E-08
GKO Esr1 1.08(0.96-1.21) Down 1.31(1.17-1.47) Down 1.28(1.14-1.43) Down 1.55(1.39-1.74) Down 1.36E-11
GKO Gnrhr 1.28(0.78-2.12) Down 3.20(1.70-6.03) Up 2.29(1.37-3.82) Down 1.80(0.96-3.35) Up 1.80E-03
GKO Kiss1 1.95(1.58-2.42) Up 1.09(0.88-1.35) Up 9.12(7.36-11.29) Down 16.34(13.19-20.23) Down 5.71E-52
GKO Klk1b22 1.25(0.71-2.20) Up 2.70(1.61-4.52) Down 1.08(0.61-1.91) Down 3.65(2.17-6.12) Down 0.0004
GKO Mmp9 1.11(0.91-1.35) Up 1.70(1.40-2.07) Up 1.11(0.92-1.35) Up 1.71(1.41-2.08) Up 2.69E-07
GKO Six2 1.05(0.73-1.50) Down 2.22(1.55-3.18) Up 1.78(1.24-2.55) Down 1.30(0.91-1.87) Up 0.0022
GKO Tec 2.48(1.95-3.14) Down 1.75(1.38-2.22) Down 1.63(1.29-2.07) Down 1.16(0.91-1.46) Down 2.03E-13
GKO Txnip 1.04(0.80-1.34) Down 1.81(1.40-2.35) Up 1.85(1.43-2.39) Down 1.02(0.79-1.32) Up 8.79E-05
KKO Acsm3 1.23(1.03-1.48) Up 1.27(1.03-1.56) Down 1.86(1.53-2.26) Up 1.19(0.98-1.45) Up 9.80E-06
KKO Klk1b22 1.30(0.92-1.84) Down 4.30(3.01-6.15) Down 1.34(0.97-1.84) Down 4.43(3.01-6.51) Down 1.75E-09
KKO Mmp9 1.03(0.68-1.56) Down 3.75(2.44-5.75) Down 1.08(0.74-1.59) Down 3.93(2.48-6.22) Down 0.0127
KKO Six2 1.08(0.84-1.40) Up 1.99(1.54-2.57) Up 1.60(1.24-2.07) Down 1.15(0.89-1.49) Up 1.14E-05
KKO Tec 1.07(0.86-1.32) Down 1.72(1.39-2.12) Up 1.63(1.32-2.02) Down 1.12(0.91-1.38) Up 1.82E-05
KKO Txnip 1.16(1.00-1.34) Down 1.22(1.06-1.41) Up 1.66(1.44-1.92) Down 1.18(1.02-1.36) Down 3.01E-08
  1. FC = fold change, CI = confidence interval, Dir = Direction relative to WT (genotype subpanel) or T (hormone subpanel). GKO = GPR54 knockout, KKO = Kisspeptin knockout.