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Table 5 Age-associated fold changes in genes involved in adipocyte differentiation

From: Characterization of age-related gene expression profiling in bone marrow and epididymal adipocytes

   Bone marrow Epididymal
Symbol Entrez Gene Name 14M 18M 14M 18M
AR androgen receptor -1.84 -2.03 -1.47 -1.82
ARL4A ADP-ribosylation factor-like 4A -1.34 1.28 -2.04 1.03
CCND1 cyclin D1 1.26 1.11 2.48 -1.64
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha -1.51 -1.43 -1.33 1.15
DDIT3 DNA-damage-inducible transcript 3 1.22 -2.14 -1.76 -1.16
EBF1 early B-cell factor 1 1.43 -1.50 -1.28 -1.41
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 1.80 1.17 1.70 1.53
FABP4 fatty acid binding protein 4, adipocyte -1.54 -2.57 -1.23 -1.32
FGF10 fibroblast growth factor 10 1.23 1.18 -2.60 1.04
FN1 fibronectin 1 1.36 -1.18 7.06 -3.16
IL6 interleukin 6 (interferon, beta 2) -2.04 -2.07 -20.53 -5.56
IL1B interleukin 1, beta 1.37 -1.48 -2.26 -2.16
INSIG1 insulin induced gene 1 1.26 1.49 1.33 2.81
IRS2 insulin receptor substrate 2 1.96 -1.13 -4.26 -2.94
LAMA4 laminin, alpha 4 -1.44 -1.38 -1.41 -1.18
LEP leptin -2.02 -1.77 1.01 1.59
LIF leukemia inhibitory factor (cholinergic differentiation factor) 1.88 1.11 -1.03 -1.07
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 1.29 1.02 1.01 1.15
PARP2 poly (ADP-ribose) polymerase 2 1.35 1.24 1.30 1.21
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha 1.41 -1.09 -1.05 2.02
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) -1.34 1.03 3.29 -1.59
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 1.43 -2.09 -3.75 -5.58
RARA retinoic acid receptor, alpha -1.30 -2.35 1.06 -1.49
RETNLA resistin like alpha -1.32 -1.11 2.96 -10.77
SCD stearoyl-CoA desaturase (delta-9-desaturase) 1.80 1.11 1.01 1.05
TNF tumor necrosis factor 2.36 -1.48 -2.37 -2.18
TRIB2 tribbles homolog 2 2.98 1.17 1.78 -1.18
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor -1.39 -1.32 -1.12 -1.21
  1. The list includes age-related fold change in genes involved in adipocytes differentiation in bone marrow and epididymal adipocytes. The set of regulated genes was selected according to the IPA knowledge-base. The 14-month (14M) and 18-month-old (18M) were compared to 6-month-old. The significance of differences was measured by two-way ANOVA. The significance of differences was estimated by a Benjamini-Hochberg corrected p value (p < 0.01).