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Table 7 Age-related fold changes in genes involved in mitochondrial function

From: Characterization of age-related gene expression profiling in bone marrow and epididymal adipocytes

   Bone marrow Epididymal
Symbol Entrez Gene Name 14M 18M 14M 18M
CASP9 caspase 9, apoptosis-related cysteine peptidase 1.51 1.38 1.27 1.23
GLRX2 glutaredoxin 2 1.36 1.79 -1.05 1.38
GPX4 glutathione peroxidase 4 (phospholipid hydroperoxidase) 1.08 1.30 -1.12 -1.11
MAOB monoamine oxidase B -1.23 -1.39 -1.06 1.31
MT-ND4L NADH dehydrogenase, subunit 4L (complex I) -1.25 -1.63 -1.22 -1.17
NDUFA4 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4, 9 kDa 1.11 1.81 -1.21 1.00
NDUFA7 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 7, 14.5 kDa -1.72 -1.69 -1.15 1.12
NDUFA11 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 11, 14.7 kDa -1.46 -1.68 -1.07 1.04
NDUFA12 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 12 -1.58 -1.71 -1.11 1.09
NDUFA13 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13 -1.05 -1.33 -1.26 -1.30
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2 -1.26 -1.38 1.50 1.05
NDUFA9 (includes EG:4704) NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9, 39 kDa 1.11 1.77 -1.46 1.10
NDUFAF1 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, assembly factor 1 1.18 1.87 -1.41 1.42
NDUFB8 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8, 19 kDa -1.31 -1.40 -1.35 1.09
NDUFB10 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 10, 22 kDa -1.46 -1.38 -1.18 1.01
NDUFB11 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 11, 17.3 kDa -1.58 -1.38 -1.18 -1.13
NDUFS1 NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75 kDa (NADH-coenzyme Q reductase) 1.29 2.22 -1.21 1.67
NDUFS4 NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18 kDa (NADH-coenzyme Q reductase) -1.22 -1.39 -1.03 1.48
NDUFS7 NADH dehydrogenase (ubiquinone) Fe-S protein 7, 20 kDa (NADH-coenzyme Q reductase) -1.53 -1.51 -1.16 -1.08
NDUFS8 NADH dehydrogenase (ubiquinone) Fe-S protein 8, 23 kDa (NADH-coenzyme Q reductase) -1.37 -1.52 1.14 1.46
NDUFS6 (includes EG:4726) NADH dehydrogenase (ubiquinone) Fe-S protein 6, 13 kDa (NADH-coenzyme Q reductase) 1.01 1.68 -1.08 1.29
NDUFV2 NADH dehydrogenase (ubiquinone) flavoprotein 2, 24 kDa -1.54 -1.31 -1.27 1.26
NDUFV3 NADH dehydrogenase (ubiquinone) flavoprotein 3, 10 kDa -1.24 -1.38 -1.11 -1.12
PDHA1 (includes EG:5160) pyruvate dehydrogenase (lipoamide) alpha 1 1.62 1.85 -1.20 1.45
PRDX3 peroxiredoxin 3 1.19 2.39 -1.42 1.19
SDHA succinate dehydrogenase complex, subunit A, flavoprotein (Fp) 1.31 1.51 -1.35 1.06
SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip) -1.25 -1.31 -1.35 1.10
SNCA synuclein, alpha (non A4 component of amyloid precursor) -1.08 1.67 -1.16 -3.22
UQCRFS1 ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1 1.20 1.49 -1.68 -1.05
UQCRH ubiquinol-cytochrome c reductase hinge protein -1.14 -1.32 -1.27 1.24
  1. The list includes the mitochondrial genes that change with age in bone marrow and epididymal adipocytes. The set of regulated genes was selected on the basis of their expression in adipose cells according to the IPA knowledge-base. For each gene, the fold change value in gene expression was calculated between mean values in bone marrow adipocytes. The 14-month (14M) and 18-month-old (18M) were compared to 6-month-old. The significance of differences was measured by two-way ANOVA.