S. mansoni ePKs domain architectures. Representative domain organizations of some S. mansoni ePKs belonging to the AGC, CaMK, CK1, CMGC, and STE groups are shown. Each protein ID and classification is shown below each image. Abbreviations followed are: PK_Domain (Protein kinase domain), PH_Domain (Pleckstrin Homology domain), Na_K_ATPase (Sodium/potassium ATPase beta chain), PK_C- (Protein Kinase C terminal domain), Zf-C3HC4 (zinc-finger, C3HC4 type RING finger), HR1 (Hr1 repeat), PB1 (Phox and Bem1p domain), C1_1 (Phorbol esters/diacylglycerol binding domain), C2 (Ca2+-dependent domain), CNH (citron homology domain), cNMP_binding (cyclic nucleotide-binding domain), Cofilin_ADF (Cofilin/tropomyosin-type actin-binding protein), CaMKII_AD (Calcium/calmodulin dependent protein kinase II Association), HD (HD homeobox domain), L27 (L27 domain), PDZ (PDZ domain, also known as DHR or GLGF), SH3_2 (Variant SH3 domain), Guanylate_kin (Guanylate kinase), UPF0061 (Uncharacterized ACR, YdiU/UPF0061 family), Ig (Immunoglobulin domain), fn3 (Fibronectin type III domain), V-set (Immunoglobulin V-set domain), FHA (Forkhead-associated domain), and PBD (P21-Rho-binding domain). The protein domain architectures were generated using DOG 1.0  based on the Pfam domain limits .