Skip to main content

Table 2 Orthology relationships among ePKs of S. mansoni, B. malayi, and C. elegans and RNAi phenotype for C. elegans proteins

From: Eukaryotic Protein Kinases (ePKs) of the Helminth Parasite Schistosoma mansoni

Group

S. mansoni

C. elegans

Brugi malayi

C. elegans RNAi phenotype

CaMK

 

Smp_053560

C44C8.6_Ce e K08F8.1

-

Embryonic Lethal

AGC

 

Smp_123640

F19C6.1_Ce

-

Embryonic lethal, maternal sterile, organism morphology variant.

 

Smp_136750

Y47D3A.16_Ce

Bm1_44635

Larval lethal, fertility reduced

 

Smp_158560

K08B12.5_Ce

Bm1_02320

Body morphology defect, slow growth

 

Smp_096310

pkc-3_Ce_A

Bm1_03335

Embryonic lethal, sterile, body morphology defect

TK

 

Smp_139480

vab-1_Ce_T

Bm1_03410

Embryonic lethal, body morphology defect

STE

 

Smp_026510, Smp_151670

mek-2_Ce

-

Embryonic lethal, sterile, reduced brood size, exploted through vulva, slow growth

 

Smp_096640

gck_1_Ce

-

cortical dynamics defective early embryonic, maternal sterile

 

Smp_163420

mig_15_Ce

Bm1_32540

Abnormal cell migration, protruding vulva, developmental delay

 

Smp_068060

kin_18_Ce

Bm1_55590

Embryonic lethal, body morphology defect, slow growth, sterile, larval lethal, dumpy

 

Smp_131800

Y59A8B.23_CE

Bm1_11845

More depolarized oocytes

 

Smp_150260

C04A11.3_Ce

Bm1_26435

Slow growth, larval lethal late L3/L4

TKL

 

Smp_079760

pat4_Ce_TK

Bm1_20815

Embryonic lethal, body morphology defect, larval lethal, sterile,

paralyzed, uncoordinated movement, paralyzed

 

Smp_176990

lin45_Ce_T

Bm1_40290

Sterile, osmotic integrity problems

CMGC

 

Smp_068960

F22D6.5_Ce

Bm1_12230

Embryonic lethal, slow growth, sterile progeny, uncoordinateed movement

 

Smp_041770

spk_1_Ce

-

Embryonic lethal, larval lethal, maternal sterile

 

Smp_172700

cdk_4_Ce

-

Locomotion variant, larval lethal, sterile progeny

 

Smp_133020

pmk-1_Ce, pmk-2_Ce

-

Apoptosis increased, sterile progeny, reduced brood size, embryonic lethal

 

Smp_134260, Smp_133490, Smp_133500

C05D10.2

-

Reduced brood size, embryonic lethal

 

Smp_080730

cdk_1_Ce

-

embryonic lethal, sterile progeny

 

Smp_155720, Smp_125310, Smp_008260.1

Y18D10A.5_Ce, C44H4.6_Ce

-

Larval lethal, slow growth, embryonic lethal

 

Smp_156990

F39H11.3_Ce

Bm1_33825

Sterile

 

Smp_176620

B0495.2_Ce, ZC504.3_Ce

Bm1_17240

Embryonic lethal

 

Smp_003000

H25P06.2_Ce

-

Embryonic lethal, slow growth, uncoordinated movement

 

Smp_150040

Cdk_7_Ce

Bm1_14135

Embryonic lethal

 

Smp_140700, Smp_074080

lit_1_Ce

Bm1_130

Embryonic lethal, larval lethal

 

Smp_141230

mbk_2_Ce

Bm1_38345

Embryonic lethal, sterile progeny

  1. Orthology relationships were inferred based on phylogenetic trees. RNAi phenotype for C. elegans were visualized by recent work [68] that relied on identification and analysis of essential genes.